GUVACINE

OC(=O)C1=CCCNC1

InChIKey=QTDZOWFRBNTPQR-UHFFFAOYSA-N

InChI=1S/C6H9NO2/c8-6(9)5-2-1-3-7-4-5/h2,7H,1,3-4H2,(H,8,9)

Targets

Primary Target	Pharmacology	Potency
GABA transporter 1 8 Target ID: CHEMBL1903 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7851497	Inhibitor 8297	14.0 µM [IC50]
GABA transporter 3 6 Target ID: CHEMBL5208 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7851497	Inhibitor 8297	119.0 µM [IC50]
Betaine transporter 4 Target ID: CHEMBL3715 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7851497	Inhibitor 8297	1870.0 µM [IC50]
GABA transporter 2 3 Target ID: CHEMBL4535 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7851497	Inhibitor 8297	66.0 µM [IC50]

PubMed

Title	Date	PubMed
GABA uptake inhibitors. Design, molecular pharmacology and therapeutic aspects.	2000 Aug	10903390
Effects of GABAergic agents on anesthesia induced by halothane, isoflurane, and thiamylal in mice.	2002 May	11900777
Glutamate uptake triggers transporter-mediated GABA release from astrocytes.	2009 Sep 24	19777062
Properties of gamma frequency oscillatory activity induced in hippocampal slices from the adult GAD67-GFP (Deltaneo) mouse.	2010 Apr 6	20138847
Antiovulatory and abortifacient effects of Areca catechu (betel nut) in female rats.	2010 Oct	21206624
A possible role of the non-GAT1 GABA transporters in transfer of GABA from GABAergic to glutamatergic neurons in mouse cerebellar neuronal cultures.	2010 Sep	20512624

Name

Type

Language

GUVACINE

Common Name

English

GUVACINE [MI]

Common Name

English

1,2,5,6-TETRAHYDRO-3-PYRIDINECARBOXYLIC ACID

Systematic Name

English

1,2,5,6-TETRAHYDRONICOTINIC ACID

Systematic Name

English

Code System Code Type Description

WIKIPEDIA

GUVACINE