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Details

Stereochemistry ACHIRAL
Molecular Formula C25H25FN2O5
Molecular Weight 452.4748
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ABAPERIDONE

SMILES

OCC1=COC2=CC(OCCCN3CCC(CC3)C4=NOC5=C4C=CC(F)=C5)=CC=C2C1=O

InChI

InChIKey=ICAXEUYZCLRXKY-UHFFFAOYSA-N
InChI=1S/C25H25FN2O5/c26-18-2-4-20-23(12-18)33-27-24(20)16-6-9-28(10-7-16)8-1-11-31-19-3-5-21-22(13-19)32-15-17(14-29)25(21)30/h2-5,12-13,15-16,29H,1,6-11,14H2

HIDE SMILES / InChI
The benzisoxazolyl piperidine derivative and atypical antipsychotic abaperidone [FI 8602] is being developed by Ferrer for the treatment of schizophrenia. Abaperidone is a potent antagonist of 5-HT2A receptor and dopamine D2 receptor with IC50s of 6.2 and 17 nM.

Approval Year

PubMed

PubMed

TitleDatePubMed
Reduced basal and phencyclidine-induced expression of heat shock protein-70 in rat prefrontal cortex by the atypical antipsychotic abaperidone.
2003 Feb
Synthesis and Pharmacological Evaluation of (6-Substituted 4-Oxo-4H-chromene-3 yl) methyl N-substituted Aminoacetates.
2008 Jan
Patents

Sample Use Guides

A study of serum prolactin levels after oral administration of Abaperidone, haloperidol, and risperidone at 5 mg/kg for either 1 or 3 days in rats.
Route of Administration: Oral
In Vitro Use Guide
Abaperidone possesses good affinity for dopamine D2 receptors, together with a greater affinity for 5-HT2 receptors with IC50 of 17 and 6.2 nM, reaspectively.
Name Type Language
ABAPERIDONE
INN   WHO-DD  
INN  
Official Name English
Abaperidone [WHO-DD]
Common Name English
7-(3-(4-(6-FLUORO-1,2-BENZISOXAZOL-3-YL)PIPERIDINO)PROPOXY)-3-(HYDROXYMETHYL)-4H-1-BENZOPYRAN-4-ONE
Systematic Name English
abaperidone [INN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C29710
Created by admin on Fri Dec 15 16:04:42 GMT 2023 , Edited by admin on Fri Dec 15 16:04:42 GMT 2023
Code System Code Type Description
PUBCHEM
3037308
Created by admin on Fri Dec 15 16:04:42 GMT 2023 , Edited by admin on Fri Dec 15 16:04:42 GMT 2023
PRIMARY
SMS_ID
100000078803
Created by admin on Fri Dec 15 16:04:42 GMT 2023 , Edited by admin on Fri Dec 15 16:04:42 GMT 2023
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NCI_THESAURUS
C73280
Created by admin on Fri Dec 15 16:04:42 GMT 2023 , Edited by admin on Fri Dec 15 16:04:42 GMT 2023
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INN
7806
Created by admin on Fri Dec 15 16:04:42 GMT 2023 , Edited by admin on Fri Dec 15 16:04:42 GMT 2023
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FDA UNII
40755Z8956
Created by admin on Fri Dec 15 16:04:42 GMT 2023 , Edited by admin on Fri Dec 15 16:04:42 GMT 2023
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EVMPD
SUB00232MIG
Created by admin on Fri Dec 15 16:04:42 GMT 2023 , Edited by admin on Fri Dec 15 16:04:42 GMT 2023
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ChEMBL
CHEMBL2104001
Created by admin on Fri Dec 15 16:04:42 GMT 2023 , Edited by admin on Fri Dec 15 16:04:42 GMT 2023
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CAS
183849-43-6
Created by admin on Fri Dec 15 16:04:42 GMT 2023 , Edited by admin on Fri Dec 15 16:04:42 GMT 2023
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EPA CompTox
DTXSID20171488
Created by admin on Fri Dec 15 16:04:42 GMT 2023 , Edited by admin on Fri Dec 15 16:04:42 GMT 2023
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MESH
C116717
Created by admin on Fri Dec 15 16:04:42 GMT 2023 , Edited by admin on Fri Dec 15 16:04:42 GMT 2023
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