Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C14H17ClN2O2 |
| Molecular Weight | 280.75 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC2=C(NC=C2[C@@H](C)CNC(C)=O)C=C1Cl
InChI
InChIKey=RKHCTAKUYDTFHE-QMMMGPOBSA-N
InChI=1S/C14H17ClN2O2/c1-8(6-16-9(2)18)11-7-17-13-5-12(15)14(19-3)4-10(11)13/h4-5,7-8,17H,6H2,1-3H3,(H,16,18)/t8-/m0/s1
LY-156735 (TIK-301) is a melatonergic agonist and serotonergic antagonist drug. In May 2004 the FDA granted orphan drug designation to TIK-301 for the treatment of circadian sleep disorders in totally blind individuals as well as in individuals with tardive dyskinesia. Theoretically, it has an antidepressant effect.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| A single blind, placebo controlled, across groups dose escalation study of the safety, tolerability, pharmacokinetics and pharmacodynamics of the melatonin analog beta-methyl-6-chloromelatonin. | 2004 Aug 27 |
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| Melatonin receptor agonists: SAR and applications to the treatment of sleep-wake disorders. | 2008 |
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| A Review of Melatonin, Its Receptors and Drugs. | 2016 Jun |
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| Classification Tree | Code System | Code | ||
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FDA ORPHAN DRUG |
147501
Created by
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FDA ORPHAN DRUG |
157102
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admin on Fri Dec 15 15:32:26 GMT 2023 , Edited by admin on Fri Dec 15 15:32:26 GMT 2023
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3ZX95B1ZWK
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118702-11-7
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C489883
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DTXSID70922760
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219018
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LY-156,735
Created by
admin on Fri Dec 15 15:32:26 GMT 2023 , Edited by admin on Fri Dec 15 15:32:26 GMT 2023
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PRIMARY |
ACTIVE MOIETY
