Cinmetacin is a synthetic non-steroidal anti-inflammatory agent that belongs to the class of heteroaryl acetic acid derivatives. The anti-inflammatory activity of cinmetacin is attributed to the inhibition of the enzyme prostaglandin synthetase. In addition to anti-inflammatory activity, cinmetacin also possesses analgesic and antipyretic properties. It is indicated in the management of pain and inflammatory in conditions such as rheumatoid arthritis, ankylosing spondylitis, and acute gout. Unfortunately, the clinical use of cinmetacin is seriously limited owing to adverse effects such as gastric ulceration and haemorrhage, the most frequent of all adverse effects pertaining to administration of NSAIDs