Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C29H27NO8 |
| Molecular Weight | 517.5266 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)CCC1=C(OCC2=CC=C3C(=O)NOC3=C2)C=CC(=C1)C(=O)C4=C(O)C=C(OC5CCCC5)C=C4
InChI
InChIKey=DALCQQSLNPLQFZ-UHFFFAOYSA-N
InChI=1S/C29H27NO8/c31-24-15-21(37-20-3-1-2-4-20)8-10-22(24)28(34)19-6-11-25(18(14-19)7-12-27(32)33)36-16-17-5-9-23-26(13-17)38-30-29(23)35/h5-6,8-11,13-15,20,31H,1-4,7,12,16H2,(H,30,35)(H,32,33)
Approval Year
Cmax
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
240 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/18587386/ |
10 mg/kg bw single, oral dose: 10 mg/kg bw route of administration: Oral experiment type: SINGLE co-administered: |
R-7277 plasma | Mus musculus population: UNHEALTHY age: ADULT sex: MALE food status: UNKNOWN |
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23626877
Created by
admin on Mon Mar 31 23:45:44 GMT 2025 , Edited by admin on Mon Mar 31 23:45:44 GMT 2025
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R-7277
Created by
admin on Mon Mar 31 23:45:44 GMT 2025 , Edited by admin on Mon Mar 31 23:45:44 GMT 2025
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PRIMARY | Inhibitory activities: The DNA binding activity of transcription factors was measured using the TransAM kits (Active Motif). Nuclear extracts containing factors such as c-Fos/AP-1, c-Jun/AP-1, ATF-2, C/EBPa, MyoD, Sp-1 or NF-kB/p65 and various concentrations of T-5224 were added in the multi-well plates precoated with respective consensus double-stranded (ds)DNA oligomers. After incubation for 1 h, the transcription factor bound to its respective consensus dsDNA sequences was detected by using antibodies reactive against the respective transcription factors according to the manufacturers protocol. | ||
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530141-72-1
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admin on Mon Mar 31 23:45:44 GMT 2025 , Edited by admin on Mon Mar 31 23:45:44 GMT 2025
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DTXSID201026089
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admin on Mon Mar 31 23:45:44 GMT 2025 , Edited by admin on Mon Mar 31 23:45:44 GMT 2025
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3Z4EGU4HKZ
Created by
admin on Mon Mar 31 23:45:44 GMT 2025 , Edited by admin on Mon Mar 31 23:45:44 GMT 2025
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ACTIVE MOIETY
