ZOLOPERONE

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	C22H24FN3O3
Molecular Weight	397.4427
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=C(C=CC=C1)N2CCN(CCC3=C(NC(=O)O3)C4=CC=C(F)C=C4)CC2

InChI

InChIKey=FCMGKQUKZIJJSH-UHFFFAOYSA-N

InChI=1S/C22H24FN3O3/c1-28-19-5-3-2-4-18(19)26-14-12-25(13-15-26)11-10-20-21(24-22(27)29-20)16-6-8-17(23)9-7-16/h2-9H,10-15H2,1H3,(H,24,27)

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Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6109537 | https://www.ncbi.nlm.nih.gov/pubmed/7379927 | http://www.armchairpatriot.com/Encyclopedias/Encyclopedia-Pharmaceutical%20Manufacturing%20(3rd%20edition)/15265_v04_09.pdf

Zoloperone (LR 511) is a neuroleptic drug. Zoloperone was almost inactive in controlling unconditioned escape response (UER). Daily treatment with LR 511 for 7-16 days did not cause the appearance of tolerance in young and adult rats, on the contrary, made in evidence a stronger effect on CAR and on UER. Oral administration of LR 511 induced in male rats a marked, dose-dependent and sustained rise of plasma prolactin.

Originator

Approval Year

PubMed

Title	Date	PubMed
Behavioral, anti-dopaminergic, and prohypnotic effects of neuroleptics during and after prolonged treatment.	1980	6105785
Classical neuroleptics and deconditioning activity after single or repeated treatment. Role of different cerebral neurotransmitters.	1980	6109537

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Oral

Name

Type

Language

ZOLOPERONE

Official Name

English

zoloperone [INN]

Preferred Name

English

Classification Tree Code System Code

NCI_THESAURUS

C28197