Details
Stereochemistry | ACHIRAL |
Molecular Formula | C17H14N2O3 |
Molecular Weight | 294.3047 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCN1C=C(C(O)=O)C(=O)C2=CC=C(C=C12)C3=CC=NC=C3
InChI
InChIKey=XBPZXDSZHPDXQU-UHFFFAOYSA-N
InChI=1S/C17H14N2O3/c1-2-19-10-14(17(21)22)16(20)13-4-3-12(9-15(13)19)11-5-7-18-8-6-11/h3-10H,2H2,1H3,(H,21,22)
Rosoxacin, a quinolone derivative, is an antibiotic, which is used for the treatment of uncomplicated acute gonococcal urethritis. Administration of rosoxacin is an effective regimen for the therapy of chancroid and is a reasonable alternative to other short-course regimens. The drug binds to and inhibits two enzymes topoisomerase II (DNA gyrase), which is required for bacterial DNA replication, transcription, repair, and recombination.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: CHEMBL2311244 Sources: https://www.ncbi.nlm.nih.gov/pubmed/3010848 |
PubMed
Title | Date | PubMed |
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Anti-Mycobacterium avium activity of quinolones: in vitro activities. | 1993 Sep |
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Antiviral properties of 3-quinolinecarboxamides: a series of novel non-nucleoside antiherpetic agents. | 1997 May |
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Selective Spectrophotometric and Spectrofluorometric Methods for the Determination of Amantadine Hydrochloride in Capsules and Plasma via Derivatization with 1,2-Naphthoquinone-4-sulphonate. | 2009 |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1966732
a single 300 mg capsule
Route of Administration:
Oral
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NCI_THESAURUS |
C795
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WHO-ATC |
J01MB01
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QJ01MB01
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SUB10389MIG
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m9670
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100000084362
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3903
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35797
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CHEMBL291157
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254-758-4
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DB00817
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C76232
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ROSOXACIN
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287180
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ACTIVE MOIETY