HYGROMYCIN B

Details

Stereochemistry	EPIMERIC
Molecular Formula	C20H37N3O13
Molecular Weight	527.5201
Optical Activity	UNSPECIFIED
Defined Stereocenters	15 / 16
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12OC4(O[C@]1([H])[C@H](O[C@]3([H])[C@@H](O)[C@H](N)C[C@H](NC)[C@H]3O)O[C@H](CO)[C@@H]2O)O[C@]([H])([C@@H](N)CO)[C@H](O)[C@H](O)[C@H]4O

InChI

InChIKey=GRRNUXAQVGOGFE-HUCHGKBZSA-N

InChI=1S/C20H37N3O13/c1-23-7-2-5(21)9(26)15(10(7)27)33-19-17-16(11(28)8(4-25)32-19)35-20(36-17)18(31)13(30)12(29)14(34-20)6(22)3-24/h5-19,23-31H,2-4,21-22H2,1H3/t5-,6+,7+,8-,9+,10-,11+,12-,13+,14-,15-,16+,17+,18-,19+,20?/m1/s1

HIDE SMILES / InChI

Description
Sources: https://www.elanco.us/labels/Poultry/Hygromix_8.pdf | http://www.invivogen.com/hygromycin | https://www.ncbi.nlm.nih.gov/pubmed/18567815

Hygromycin B is a water-soluble antibiotic purified from the bacterium Streptomyces hydroscopicus.It kills bacteria, fungi and higher eukaryotic cells by inhibiting protein synthesis. It has been reported to interfere with translocation and to cause mistranslation at the 70S ribosome.Hygromycin B is used as a selective agent in molecular genetics experiments on a wide variety of eukaryotic and prokaryotic species. Under the trade name Hygromix, Hygromycin B is used in chickens as an aid in the control of infections of the following intestinal parasites: large roundworms (Ascaris galli), cecal worms (Heterakis gallinae) and capillary worms (Capillaria obsignata) and in Swine as an aid in the control of infections of the following intestinal parasites: large roundworms (Ascaris suis), nodular worms (Oesophagostomum dentatum) and whipworms (Trichuris suis).

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Bacterial 70S ribosome 179 Target ID: CHEMBL2363135 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18567815 \| https://www.ncbi.nlm.nih.gov/pubmed/17043113 \| https://www.ncbi.nlm.nih.gov/pubmed/11163189	Inhibitor 8297
Ribosome-associated ATPase 1 Target ID: P37624 Gene ID: 947998.0 Gene Symbol: rbbA Target Organism: Escherichia coli (strain K12) Sources: https://www.ncbi.nlm.nih.gov/pubmed/11557474	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Helminthiasis in chickens and swine 1 Sources: https://www.elanco.us/labels/Poultry/Hygromix_8.pdf https://hencam.com/henblog/2014/05/wormer-warning/	Curative		Approved 8429	Hygromix 8 Approved Use Chickens: As an aid in the control of infections of the following intestinal parasites: Large roundworms (Ascaris galli), cecal worms (Heterakis gallinae) and capillary worms (Capillaria obsignata). 8 to 12 g/ton Swine: As an aid in the control of infections of the following intestinal parasites: Large roundworms (Ascaris suis), nodular worms (Oesophagostomum dentatum) and whipworms (Trichuris suis). Launch Date 1986

PubMed

Title	Date	PubMed

Patents

Sample Use Guides

In Vivo Use Guide

Chickens: Thoroughly mix Hygromix 8 Type A Medicated Article with feed to provide a Type B medicated feed containing up to 132 grams hygromycin B per ton or to provide a complete Type C medicated feed containing 8 to 12 g hygromycin B per ton. When manufacturing Type C medicated feed by directly mixing Hygromix 8 with the finished feed, thoroughly mix Hygromix 8 with a small quantity of finished feed before incorporation into the bulk of the finished feed. Swine: Thoroughly mix Hygromix 8 Type A Medicated Article with feed to provide a Type B medicated feed containing up to 132 grams hygromycin B per ton or to provide a complete Type C medicated feed containing 12 g hygromycin B per ton. When manufacturing Type C medicated feed by directly mixing Hygromix 8 with the finished feed, thoroughly mix Hygromix 8 with a small quantity of finished feed before incorporation into the bulk of the finished feed.

Route of Administration: Oral

In Vitro Use Guide

The MIC for hygromycin B in E. coli cells growing in TSB was found to be 150 g/ml. The 50% inhibitory concentration (IC50) for inhibition of translation was 16 g/ml.

Name

Type

Language

HYGROMYCIN B

Common Name

English

HYGROMYCIN B [MART.]

Common Name

English

HYGROVETIN

Common Name

English

HYGROMIX

Brand Name

English

ANTIHELMYCIN

Common Name

English

HYGROMYCIN B [GREEN BOOK]

Common Name

English

HYGROMYCIN B [MI]

Common Name

English

O-6-AMINO-6-DEOXY-L-GLYCERO-D-GALACTO-HEPTOPYRANOSYLIDENE-(1->2-3)-O-.BETA.-D-TALOPYRANOSYL-(1->5)-2-DEOXY-N3-METHYL-D-STREPTAMINE

Common Name

English

HYGROVETINE

Common Name

English

Classification Tree Code System Code

CFR

21 CFR 556.330