| Stereochemistry | ABSOLUTE |
| Molecular Formula | C27H42O4 |
| Molecular Weight | 430.62 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 12 / 12 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
C[C@H]1[C@H]2[C@H](C[C@H]3[C@@H]4CC[C@H]5C[C@@H](O)CC[C@]5(C)[C@H]4CC(=O)[C@]23C)O[C@]16CC[C@@H](C)CO6
InChI
InChIKey=QOLRLLFJMZLYQJ-LOBDNJQFSA-N
InChI=1S/C27H42O4/c1-15-7-10-27(30-14-15)16(2)24-22(31-27)12-21-19-6-5-17-11-18(28)8-9-25(17,3)20(19)13-23(29)26(21,24)4/h15-22,24,28H,5-14H2,1-4H3/t15-,16+,17+,18+,19-,20+,21+,22+,24+,25+,26-,27-/m1/s1
Hecogenin is the steroidal saponin aglycone (or sapogenin) present in the leaves of species from the Agave genus, including Agave sisalana, Agave cantala and Agave aurea. Hecogenin has a wide spectrum of pharmacological activities already studied, including anticancer/antiproliferative, antifungal and hipotensive activities. A recent study showed that this substance is a selective inhibitor of human UDP-glucuronosyltransferases, enzymes responsible for the detoxification of numerous chemical toxins
Originator
Approval Year
PubMed
Patents
Sample Use Guides
The anti-inflammatory effects of Hecogenin (50 µg/animal) was investigated on various inflammatory models. The anti-inflammatory effect of HG, was studied on % inhibition of dry weight of granuloma tissue, Δ ear weight, myeloperoxidase assay, serum pro-inflammatory cytokines, colon weight to length ratio, macroscopic lesions, adhesion score, diarrhoea score and histopathological analysis of ear and colon tissue on Cotton pellets induced granuloma in rats, Croton oil induced ear edema in mice and TNBS induced granuloma in rats.
Route of Administration:
Topical
SUBSTANCE RECORD
