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Details

Stereochemistry ACHIRAL
Molecular Formula Al
Molecular Weight 26.9815
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 3

SHOW SMILES / InChI
Structure of ALUMINUM CATION

SMILES

[Al+3]

InChI

InChIKey=REDXJYDRNCIFBQ-UHFFFAOYSA-N
InChI=1S/Al/q+3

HIDE SMILES / InChI

Description
Curator's Comment:: Description was created based on several sources, including https://www.google.com/patents/US2824042 | https://www.ncbi.nlm.nih.gov/pubmed/22718290 | https://www.ncbi.nlm.nih.gov/pubmed/15516810 | https://www.ncbi.nlm.nih.gov/pubmed/10211213 | https://www.drugs.com/monograph/aluminum-acetate.html

Burow invented an astringent antiseptic solution of aluminium acetate in water to relieve the itching and inflammation of minor skin irritations. At present the oflicial U. S. P. procedure to made Burow's solution involves the reaction of aluminum sulfate, calcium carbonate and acetic acid to form aluminum sub-acetate, also termed basic aluminum acetate. The solution is available as an over-the-counter drug for topical administration, with brand names including Domeboro. Burow's solution has been shown to be effective against chronic suppurative otitis media and otitis externa. It is active against bacteria resulting in damage to the cell wall.

Originator

Curator's Comment:: Burow invented an astringent antiseptic solution of aluminium acetate in water to relieve the itching and inflammation of minor skin irritations

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
DOMEBORO

Approved Use

Temporarily relieves minor skin irritations due to: – Poison ivy | – Poison oak – Poison sumac | – Insect bites – Athlete’s foot | – Rashes caused by soaps, detergents, cosmetics, or jewelry
Curative
DOMEBORO

Approved Use

This medication is used to treat an outer ear infection (external otitis). This product contains acetic acid/aluminum acetate, a combination that stops the growth of bacteria and fungus. Treating the infection reduces pain and swelling in the ear. Wetness in the ear canal can help bacteria and fungus to grow. This medication also causes drying of the ear canal, helping to cure the infection.
PubMed

PubMed

TitleDatePubMed
The ineffectiveness of aluminum subacetate in rheumatoid arthritis.
1948 Apr 8
Aluminum fluoride induces phosphatidylinositol turnover, elevation of cytoplasmic free calcium, and phosphorylation of the T cell antigen receptor in murine T cells.
1987 Nov 15
Cardiovascular manifestations of aluminium phosphide intoxication.
1989 Sep
Effect of aluminum phosphide on blood glucose level.
1999 Feb
Effects of trace metal compounds on HIV-1 reverse transcriptase: an in vitro study.
1999 May
Cholinesterase inhibition by aluminium phosphide poisoning in rats and effects of atropine and pralidoxime chloride.
2001 Jan
Fluoride plus aluminum: useful tools in laboratory investigations, but messengers of false information.
2002
Parenteral nutrition-associated cholestasis in neonates: the role of aluminum.
2003 Sep
The influence of alumina and ultra-high molecular weight polyethylene particles on osteoblast-osteoclast cooperation.
2004 Aug
The giant protein HERC1 is recruited to aluminum fluoride-induced actin-rich surface protrusions in HeLa cells.
2004 Feb 13
Aluminum: new recognition of an old problem.
2005 Dec
Effects of aluminum on the nervous system and its possible link with neurodegenerative diseases.
2005 Nov
Microdermabrasion with and without aluminum oxide crystal abrasion: a comparative molecular analysis of dermal remodeling.
2006 Mar
Ototoxic effect of Burow solution applied to the guinea pig middle ear.
2007 Aug
Human macrophage response to UHMWPE, TiAlV, CoCr, and alumina particles: analysis of multiple cytokines using protein arrays.
2008 Feb
The effects of implant surface nanoscale features on osteoblast-specific gene expression.
2009 Sep
Zeta potential and solubility to toxic ions as mechanisms of lung inflammation caused by metal/metal oxide nanoparticles.
2012 Apr
Al₂O₃ nanoparticles induce mitochondria-mediated cell death and upregulate the expression of signaling genes in human mesenchymal stem cells.
2012 Nov
Effect of acute aluminum phosphide exposure on rats: a biochemical and histological correlation.
2012 Nov 23
Atomic layer deposition coating of carbon nanotubes with aluminum oxide alters pro-fibrogenic cytokine expression by human mononuclear phagocytes in vitro and reduces lung fibrosis in mice in vivo.
2014
Toxicoproteomic analysis of pulmonary carbon nanotube exposure using LC-MS/MS.
2015 Mar 2
Patents

Sample Use Guides

DOMEBORO® SOOTHING SOAK – dissolve 1 to 3 packets in a pint (16 oz) of cool or warm water – stir until fully dissolved; do not strain or filter. The resulting mixture contains 0.16% (1 packet), 0.32% (2 packets), or 0.48% (3 packets) aluminum acetate and is ready for use For use as a soak: – soak affected area for 15 to 30 minutes as needed, or as directed by a doctor – repeat 3 times a day or as directed by a doctor – discard solution after each use. For use as a compress or wet dressing: – soak a clean, soft cloth in the solution. – apply cloth loosely to affected area for 15 to 30 minutes – repeat as needed or as directed by a doctor – discard solution after each use
Route of Administration: Topical
Burow's solution (13% aluminum subacetate) is active against S. aureus and P. aeruginosa, resulting in damage to the cell wall.
Name Type Language
ALUMINUM CATION
Common Name English
ALUMINIUM, ION (AL3+)
Common Name English
ALUMINUM ION
Common Name English
ALUMUNUM ION
Common Name English
ALUMINUM(III)
Systematic Name English
AL3+
Common Name English
ALUMINUM(III) ION
Common Name English
ALUMINUM(3+)
Systematic Name English
ALUMINIUM CATION
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C68232
Created by admin on Sat Jun 26 04:19:53 UTC 2021 , Edited by admin on Sat Jun 26 04:19:53 UTC 2021
NCI_THESAURUS C597
Created by admin on Sat Jun 26 04:19:53 UTC 2021 , Edited by admin on Sat Jun 26 04:19:53 UTC 2021
Code System Code Type Description
NCI_THESAURUS
C68233
Created by admin on Sat Jun 26 04:19:53 UTC 2021 , Edited by admin on Sat Jun 26 04:19:53 UTC 2021
PRIMARY
PUBCHEM
104727
Created by admin on Sat Jun 26 04:19:53 UTC 2021 , Edited by admin on Sat Jun 26 04:19:53 UTC 2021
PRIMARY
RXCUI
1546162
Created by admin on Sat Jun 26 04:19:53 UTC 2021 , Edited by admin on Sat Jun 26 04:19:53 UTC 2021
PRIMARY RxNorm
DRUG BANK
DB14519
Created by admin on Sat Jun 26 04:19:53 UTC 2021 , Edited by admin on Sat Jun 26 04:19:53 UTC 2021
PRIMARY
FDA UNII
3XHB1D032B
Created by admin on Sat Jun 26 04:19:53 UTC 2021 , Edited by admin on Sat Jun 26 04:19:53 UTC 2021
PRIMARY
CAS
22537-23-1
Created by admin on Sat Jun 26 04:19:53 UTC 2021 , Edited by admin on Sat Jun 26 04:19:53 UTC 2021
PRIMARY