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Details

Stereochemistry RACEMIC
Molecular Formula C18H22ClNO
Molecular Weight 303.826
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CHLORPHENOXAMINE

SMILES

CN(C)CCOC(C)(C1=CC=CC=C1)C2=CC=C(Cl)C=C2

InChI

InChIKey=KKHPNPMTPORSQE-UHFFFAOYSA-N
InChI=1S/C18H22ClNO/c1-18(21-14-13-20(2)3,15-7-5-4-6-8-15)16-9-11-17(19)12-10-16/h4-12H,13-14H2,1-3H3

HIDE SMILES / InChI

Description
Curator's Comment: Description was created based on several sources, including https://www.drugs.com/international/systral.html http://en.pharmacodia.com/web/drug/1_10746.html

Chlorphenoxamine is an antihistamine and anticholinergic used as an antipruritic and was formerly used in the sympathomimetic treatment of parkinsonism. Histamine receptor H1 antagonist. Chlorphenoxamine is used to treat Allergic conditions, it is reported as an ingredient of Systral in Germany, Malta, Portugal, Thailand, Turkey.

CNS Activity

Originator

Approval Year

1959
143
Targets

Targets

Primary TargetPharmacologyConditionPotency
Antagonist
2849
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8583
CHLORPHENOXAMINE

Approved Use

Allergic conditions
Doses

Doses

DosePopulationAdverse events​
600 mg multiple, oral
Highest studied dose
Dose: 600 mg
Route: oral
Route: multiple
Dose: 600 mg
Sources:
https://pubmed.ncbi.nlm.nih.gov/13640980
unhealthy
Health Status: unhealthy
Sex: M+F
Sources:
https://pubmed.ncbi.nlm.nih.gov/13640980
Sources:
https://pubmed.ncbi.nlm.nih.gov/13640980
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG

OverviewOther

Other InhibitorOther SubstrateOther Inducer
P-gp
1741
Drug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
P-gp
1932
 inconclusive
Sourcing

Sourcing

Vendor/AggregatorIDURL
001 Chemical
DY571136
https://www.001chemical.com/chem/77-38-3
3B Scientific (Wuhan) Corp
3B2-1316
http://www.3bsc.com/index/pro_info.php?id=55032
AA Blocks
AA005MX8
https://www.aablocks.com/goods/Goods/detail?id=AA005MX8
abcr GmbH
AB436231
http://www.abcr.com/shop/en/AB436231
AbMole Bioscience
M5514
http://www.abmole.com/products/chlorphenoxamine.html
Acadechem
ACDS-026396
http://www.acadechemical.com/product/101095
Achemtek
0102-030283
http://www.achemtek.com/77-38-3
AEchem Scientific Corp., USA
AE1-004538
http://www.aechemsc.com/info_products/AE1-004538.php
AHH Chemical co.,ltd
MT-49196
http://www.ahhchemical.com/product/MT-49196.html
AK Scientific, Inc. (AKSCI)
X5916
http://www.aksci.com/item_detail.php?cat=X5916
Ambeed
A629750
https://www.ambeed.com/products/77-38-3.html
Angel Pharmatech
AG306884
http://www.angelpharmatech.com/77-38-3.html
Anward
ANW-74407
http://www.anward.com/pro_result/60858
Ark Pharm
AK-57052
http://www.arkpharminc.com/products/77-38-3.html
BLD Pharm
BD120985
http://www.bldpharm.com/products/77-38-3.html
Chem Scene
CS-5310
http://www.chemscene.com/77-38-3.html
ChemMol
96705533
http://www.chemmol.com/chemmol/96705533.html
Chemspace
CSSB00000054720
https://chem-space.com/CSSB00000054720
CSNpharm
CSN10624
https://www.csnpharm.com/products/chlorphenoxamine.html
eNovation Chemicals
D516913
http://www.enovationchem.com/productDetails.asp?productID=D516913
Finetech
FT-0682434
http://www.finetechnology-ind.com/prod/detail/pub/77-38-3.html
Lab Network
LN00159272
https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN00159272
Matrix Scientific
57751
https://www.matrixscientific.com/057751.html
MedChem Express
HY-B1607
https://www.medchemexpress.com/Chlorphenoxamine.html
Molcore
MC571136
https://www.molcore.com/product/77-38-3
MuseChem
I004847
https://www.musechem.com/product/I004847.html
Oakwood
64585
http://www.oakwoodchemical.com/ProductsList.aspx?CategoryID=-2&txtSearch=53904&ExtHyperLink=1
Sinfoo Biotech
S010739
http://www.sinfoobiotech.com/product/1014137
Smolecule
S599332
https://www.smolecule.com/products/s599332
Synblock Inc
CB10450
http://www.synblock.com/product/77-38-3.html
THE BioTek
bt-301978
https://www.thebiotek.com/product/others/bt-301978
PubMed

PubMed

TitleDatePubMed
Patents

Patents

CA1257200A
3
US20140094438
6
US4938960
3

Sample Use Guides

In Vivo Use Guide
Topical/Cutaneous Allergic conditions Adult: Apply when required several times daily.
Route of Administration: Topical
In Vitro Use Guide
Unknown
Name Type Language
CHLORPHENOXAMINE [MI]
Preferred Name English
CHLORPHENOXAMINE
INN   MI   WHO-DD  
INN  
Official Name English
Chlorphenoxamine [WHO-DD]
Common Name English
ETHENAMINE, 2-(1-(4-CHLOROPHENYL)-1-PHENYLETHOXY)-N,N-DIMETHYL-
Systematic Name English
chlorphenoxamine [INN]
Common Name English
2-((P-CHLORO-.ALPHA.-METHYL-.ALPHA.-PHENYLBENZYL)OXY)-N,N-DIMETHYLETHYLAMINE
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C29704
Created by admin on Mon Mar 31 18:40:13 GMT 2025 , Edited by admin on Mon Mar 31 18:40:13 GMT 2025
WHO-VATC QR06AA06
Created by admin on Mon Mar 31 18:40:13 GMT 2025 , Edited by admin on Mon Mar 31 18:40:13 GMT 2025
WHO-VATC QR06AA56
Created by admin on Mon Mar 31 18:40:13 GMT 2025 , Edited by admin on Mon Mar 31 18:40:13 GMT 2025
WHO-ATC D04AA34
Created by admin on Mon Mar 31 18:40:13 GMT 2025 , Edited by admin on Mon Mar 31 18:40:13 GMT 2025
WHO-VATC QD04AA34
Created by admin on Mon Mar 31 18:40:13 GMT 2025 , Edited by admin on Mon Mar 31 18:40:13 GMT 2025
WHO-ATC R06AA56
Created by admin on Mon Mar 31 18:40:13 GMT 2025 , Edited by admin on Mon Mar 31 18:40:13 GMT 2025
NCI_THESAURUS C29578
Created by admin on Mon Mar 31 18:40:13 GMT 2025 , Edited by admin on Mon Mar 31 18:40:13 GMT 2025
WHO-ATC R06AA06
Created by admin on Mon Mar 31 18:40:13 GMT 2025 , Edited by admin on Mon Mar 31 18:40:13 GMT 2025
Code System Code Type Description
EVMPD
SUB06204MIG
Created by admin on Mon Mar 31 18:40:13 GMT 2025 , Edited by admin on Mon Mar 31 18:40:13 GMT 2025
PRIMARY
SMS_ID
100000081872
Created by admin on Mon Mar 31 18:40:13 GMT 2025 , Edited by admin on Mon Mar 31 18:40:13 GMT 2025
PRIMARY
INN
885
Created by admin on Mon Mar 31 18:40:13 GMT 2025 , Edited by admin on Mon Mar 31 18:40:13 GMT 2025
PRIMARY
FDA UNII
3UVD77BP8R
Created by admin on Mon Mar 31 18:40:13 GMT 2025 , Edited by admin on Mon Mar 31 18:40:13 GMT 2025
PRIMARY
MERCK INDEX
m3457
Created by admin on Mon Mar 31 18:40:13 GMT 2025 , Edited by admin on Mon Mar 31 18:40:13 GMT 2025
PRIMARY Merck Index
NCI_THESAURUS
C81131
Created by admin on Mon Mar 31 18:40:13 GMT 2025 , Edited by admin on Mon Mar 31 18:40:13 GMT 2025
PRIMARY
EPA CompTox
DTXSID5022805
Created by admin on Mon Mar 31 18:40:13 GMT 2025 , Edited by admin on Mon Mar 31 18:40:13 GMT 2025
PRIMARY
DRUG BANK
DB09007
Created by admin on Mon Mar 31 18:40:13 GMT 2025 , Edited by admin on Mon Mar 31 18:40:13 GMT 2025
PRIMARY
DRUG CENTRAL
617
Created by admin on Mon Mar 31 18:40:13 GMT 2025 , Edited by admin on Mon Mar 31 18:40:13 GMT 2025
PRIMARY
MESH
C100100
Created by admin on Mon Mar 31 18:40:13 GMT 2025 , Edited by admin on Mon Mar 31 18:40:13 GMT 2025
PRIMARY
PUBCHEM
6475
Created by admin on Mon Mar 31 18:40:13 GMT 2025 , Edited by admin on Mon Mar 31 18:40:13 GMT 2025
PRIMARY
RXCUI
20881
Created by admin on Mon Mar 31 18:40:13 GMT 2025 , Edited by admin on Mon Mar 31 18:40:13 GMT 2025
PRIMARY RxNorm
WIKIPEDIA
CHLORPHENOXAMINE
Created by admin on Mon Mar 31 18:40:13 GMT 2025 , Edited by admin on Mon Mar 31 18:40:13 GMT 2025
PRIMARY
CAS
77-38-3
Created by admin on Mon Mar 31 18:40:13 GMT 2025 , Edited by admin on Mon Mar 31 18:40:13 GMT 2025
PRIMARY
ChEMBL
CHEMBL2110774
Created by admin on Mon Mar 31 18:40:13 GMT 2025 , Edited by admin on Mon Mar 31 18:40:13 GMT 2025
PRIMARY
NIH
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