Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C15H19IN4S |
| Molecular Weight | 414.308 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
IC1=CC=C(CCNC(=N)SCCCC2=CNC=N2)C=C1
InChI
InChIKey=UBHYDQAARZKHEZ-UHFFFAOYSA-N
InChI=1S/C15H19IN4S/c16-13-5-3-12(4-6-13)7-8-19-15(17)21-9-1-2-14-10-18-11-20-14/h3-6,10-11H,1-2,7-9H2,(H2,17,19)(H,18,20)
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Implementation of a fluorescence-based screening assay identifies histamine H3 receptor antagonists clobenpropit and iodophenpropit as subunit-selective N-methyl-D-aspartate receptor antagonists. | 2010-06 |
|
| Histamine-induced itch and its relationship with pain. | 2008-07-31 |
|
| Antagonist affinity measurements at the Gi-coupled human histamine H3 receptor expressed in CHO cells. | 2008-06-06 |
|
| Comparison of the binding distribution of agonist and antagonist ligands for histamine H3 receptors in pig brain by quantitative autoradiography. | 2007-06-14 |
|
| Role of substance P on histamine H(3) antagonist-induced scratching behavior in mice. | 2006-04 |
|
| Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonist. | 2005-09 |
|
| Generation of cell lines for drug discovery through random activation of gene expression: application to the human histamine H3 receptor. | 2005-06 |
|
| Intracerebroventricular administration of histamine H3 receptor antagonists decreases seizures in rat models of epilepsia. | 2004-05 |
|
| Inhibitory effect of iodophenpropit, a selective histamine H3 antagonist, on amygdaloid kindled seizures. | 2004-03-15 |
|
| Histamine H3 receptors regulate vascular permeability changes in the skin of mast cell-deficient mice. | 2003-11 |
|
| Involvement of histamine H3 receptors in scratching behaviour in mast cell-deficient mice. | 2003-07 |
|
| Identification of a histamine H4 receptor on human eosinophils--role in eosinophil chemotaxis. | 2002-12-31 |
|
| Constitutive activity of histamine h(3) receptors stably expressed in SK-N-MC cells: display of agonism and inverse agonism by H(3) antagonists. | 2001-12 |
| Name | Type | Language | ||
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Preferred Name | English |
| Code System | Code | Type | Description | ||
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3035746
Created by
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3SH45L9H3Z
Created by
admin on Mon Mar 31 21:50:12 GMT 2025 , Edited by admin on Mon Mar 31 21:50:12 GMT 2025
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145196-88-9
Created by
admin on Mon Mar 31 21:50:12 GMT 2025 , Edited by admin on Mon Mar 31 21:50:12 GMT 2025
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Iodophenpropit
Created by
admin on Mon Mar 31 21:50:12 GMT 2025 , Edited by admin on Mon Mar 31 21:50:12 GMT 2025
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DTXSID20273996
Created by
admin on Mon Mar 31 21:50:12 GMT 2025 , Edited by admin on Mon Mar 31 21:50:12 GMT 2025
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PRIMARY |
SUBSTANCE RECORD
