PYRAZOLE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C3H4N2
Molecular Weight	68.0773
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

N1C=CC=N1

InChI

InChIKey=WTKZEGDFNFYCGP-UHFFFAOYSA-N

InChI=1S/C3H4N2/c1-2-4-5-3-1/h1-3H,(H,4,5)

HIDE SMILES / InChI

Approval Year

PubMed

Title	Date	PubMed
Stereochemical course of the biotransformation of isoprene monoepoxides and of the corresponding diols with liver microsomes from control and induced rats.	2000 Sep	10995255
Sodium salicylate increases CYP2E1 levels and enhances arachidonic acid toxicity in HepG2 cells and cultured rat hepatocytes.	2001 Apr	11259624
Discovery of 1-[3-(aminomethyl)phenyl]-N-3-fluoro-2'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a highly potent, selective, and orally bioavailable inhibitor of blood coagulation factor Xa.	2001 Feb 15	11170646
Selective adenosine A2A receptor antagonists.	2001 Jan-Feb	11347973
Mitochondrial targeted cytochrome P450 2E1 (P450 MT5) contains an intact N terminus and requires mitochondrial specific electron transfer proteins for activity.	2001 Jul 6	11325963
The design and synthesis of noncovalent factor Xa inhibitors.	2001 Jun	11899249
Novel anionic annelation tactics for construction of fused heteroaromatic frameworks. 1. Synthesis of 4-substituted pyrazolo[3,4-c]quinolines, 9-substituted pyrazolo[3,4-c]quinolines, and 1,4-dihydrochromeno[4,3-c]pyrazoles.	2001 Jun 15	11397156
Equilibria between alpha- and beta-agostic stabilized rotamers of secondary alkyl niobium complexes.	2001 Jun 27	11414834
Novel pyrazole cannabinoids: insights into CB(1) receptor recognition and activation.	2001 Mar	11181936
Discovery of zoniporide: a potent and selective sodium-hydrogen exchanger type 1 (NHE-1) inhibitor with high aqueous solubility.	2001 Mar 26	11277524
Tethered pyrazolyl phosphinate: pyrazolyl-N- and phosphoryl-O-metal coordination in Ph(2)P(O)[OCH(2)CH(2)(3,5-Me(2)Pz)].	2001 Nov 5	11681901
Solution structure investigation of Ru(II) complex ion pairs: quantitative NOE measurements and determination of average interionic distances.	2001 Nov 7	11686707
Selective inhibition of ICAM-1 and E-selectin expression in human endothelial cells. 2. Aryl modifications of 4-(aryloxy)thieno[2,3-c]pyridines with fine-tuning at C-2 carbamides.	2001 Oct 11	11585452
Dopamine interaction in the absence and in the presence of Cu2+ ions with macrocyclic and macrobicyclic polyamines containing pyrazole units. Crystal structures of [Cu2(L1)(H2O)2](ClO4)4 and [Cu2(H-1L3)](ClO4)3*2H2O.	2001 Oct 31	11673988
4-(N,N-dipropylamino)benzaldehyde inhibits the oxidation of all-trans retinal to all-trans retinoic acid by ALDH1A1, but not the differentiation of HL-60 promyelocytic leukemia cells exposed to all-trans retinal.	2002	11872149
Design, synthesis and biological activity of rigid cannabinoid CB1 receptor antagonists.	2002 Aug	12192147
3-Aryl pyrazolo[4,3-d]pyrimidine derivatives: Nonpeptide CRF-1 antagonists.	2002 Aug 19	12127521
Syntheses and solid state structures of tris(pyrazolyl)methane complexes of sodium, potassium, calcium, and strontium: comparison of structures with analogous complexes of lead(II).	2002 Jan 14	11782139
Spectroscopic study on charge transfer molecular complexes of pyrazole derivatives with some pi-electron acceptors.	2002 Jul	12164488
Development of a physiologically based pharmacokinetic model for methyl ethyl ketone in F344 rats.	2002 Jul 12	12133235
A mechanistic investigation of oxidative addition of methyl iodide to [Tp*Rh(CO)(L)].	2002 Jun 17	12055007
Stereo- and enantioselective alkene epoxidations: a comparative study of D4- and D2-symmetric homochiral trans-dioxoruthenium(VI) porphyrins.	2002 Jun 3	12180328
A copper(II)-pyrazole complex cation with (macro)3 imposed symmetry.	2002 Mar	11870296
New structural forms in molecular metal phosphonates: novel tri- and hexanuclear zinc(II) cages containing phosphonate and pyrazole ligands.	2002 Mar 11	11874331
Pyrazolyl-bridged iridium dimers. 18.(1) influence of metal-metal bonding on the geometry of diiridium(II) adducts and hydrido-diiridium complexes formed from the diiridium(I) prototype [Ir(mu-pz)(PPh(3))(CO)](2) (pzH = Pyrazole) by dihydrogen addition or protonation.	2002 Mar 25	11896709
Nickel complexes of bidentate [S2] and [SN] borato ligands.	2002 Mar 25	11896705
Bioaffinity purification of NADP(+)-dependent dehydrogenases: studies with alcohol dehydrogenase from Thermoanaerobacter brockii.	2002 Mar 5	11788950
Synthesis and antitumor evaluation of new polysubstituted thiazole and derived thiazolo[4, 5-d]pyrimidine systems.	2002 May	12210778
Tuning and dissecting electronic and steric effects in ammonium receptors: nonactin vs artificial receptors.	2002 May 15	11996578
Synthesis and mechanism of action of novel pyrimidinyl pyrazole derivatives possessing antiproliferative activity.	2002 Nov 4	12372531
Cytochrome P450 2E1 dependent catalytic activity and lipid peroxidation in rat blood lymphocytes.	2002 Oct 11	12270756
Structure-affinity relationships of the affinity of 2-pyrazolyl adenosine analogues for the adenosine A2A receptor.	2002 Oct 21	12270178
Synthesis and characterization of a series of (hydroperoxo)-, (alkylperoxo)-, and (mu-peroxo)palladium complexes containing the hydrotris(3,5-diisopropylpyrazolyl)borato ligand (Tp(iPr2)): (Tp(iPr2))(py)Pd-OO-X [X = H, t-Bu, Pd(Tp(iPr2))(py)] and (Tp(iPr2))(py)Pd-(mu-kappa(1):kappa(2)-OO)-PdTp(iPr2).	2002 Oct 7	12354063
Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Management of acute ethylene glycol poisoning.	2002 Sep	12204996
Dimorphic exanthema manifested as reticular maculopapular exanthema and erythema multiforme major associated with pyrazolon derivatives.	2002 Sep-Oct	12370143

Patents

Name

Type

Language

PYRAZOLE

Systematic Name

English

PYRAZOLE [MI]

Common Name

English

NSC-45410

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C29396