Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C32H37N5O5 |
Molecular Weight | 571.6667 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 4 / 4 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
N[C@@H](CC1=CC=C(O)C=C1)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)N[C@@H](CC4=CC=CC=C4)C(N)=O
InChI
InChIKey=XIJHWXXXIMEHKW-LJWNLINESA-N
InChI=1S/C32H37N5O5/c33-25(18-23-13-15-24(38)16-14-23)32(42)37-17-7-12-28(37)31(41)36-27(20-22-10-5-2-6-11-22)30(40)35-26(29(34)39)19-21-8-3-1-4-9-21/h1-6,8-11,13-16,25-28,38H,7,12,17-20,33H2,(H2,34,39)(H,35,40)(H,36,41)/t25-,26-,27-,28-/m0/s1
Tetrapeptide-15 (Endomorphin-2) is an endogenous agonist at μ-opioid receptors (μORs) in the spinal cord; it exhibits antinociceptive/analgesic, immunosuppressive, and pro-angiogenic activities. Endomorphin-2 increases pain thresholds in animal models of thermal pain and inhibits the formation of antibodies in other cellular models. In HUVECs, this peptide stimulates proliferation, migration, adhesion, and tube formation.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
0.69 nM [Ki] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | Unknown Approved UseUnknown |
|||
Sources: https://www.ncbi.nlm.nih.gov/pubmed/12706478 |
Primary | Unknown Approved UseUnknown |
||
Primary | Unknown Approved UseUnknown |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/12706478
Endomorphin-2, at doses of 3, 10 and 30 ug, i.c.v., dose-dependently inhibited the number of capsaicin-induced coughs.
Route of Administration:
Other
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/12182901
Endomorphin-2 (100 uM) produced a significant inhibition, of both the frequency (-22.8%) and the amplitude (-30.5%) of the spontaneous IPSCs in rat cardiac vagal neurons.
Name | Type | Language | ||
---|---|---|---|---|
|
Official Name | English | ||
|
Brand Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English |
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
DTXSID70415506
Created by
admin on Sat Dec 16 11:14:12 GMT 2023 , Edited by admin on Sat Dec 16 11:14:12 GMT 2023
|
PRIMARY | |||
|
SUB194730
Created by
admin on Sat Dec 16 11:14:12 GMT 2023 , Edited by admin on Sat Dec 16 11:14:12 GMT 2023
|
PRIMARY | |||
|
1986806
Created by
admin on Sat Dec 16 11:14:12 GMT 2023 , Edited by admin on Sat Dec 16 11:14:12 GMT 2023
|
PRIMARY | |||
|
141801-26-5
Created by
admin on Sat Dec 16 11:14:12 GMT 2023 , Edited by admin on Sat Dec 16 11:14:12 GMT 2023
|
PRIMARY | |||
|
5311081
Created by
admin on Sat Dec 16 11:14:12 GMT 2023 , Edited by admin on Sat Dec 16 11:14:12 GMT 2023
|
PRIMARY | |||
|
Endomorphin-2
Created by
admin on Sat Dec 16 11:14:12 GMT 2023 , Edited by admin on Sat Dec 16 11:14:12 GMT 2023
|
PRIMARY | |||
|
3PH5M0466G
Created by
admin on Sat Dec 16 11:14:12 GMT 2023 , Edited by admin on Sat Dec 16 11:14:12 GMT 2023
|
PRIMARY |
SUBSTANCE RECORD