Details
| Stereochemistry | UNKNOWN |
| Molecular Formula | C14H20N4O |
| Molecular Weight | 260.3348 |
| Optical Activity | ( + ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
C(C1CONC(=N1)C2=CN=CC=C2)N3CCCCC3
InChI
InChIKey=QWVRTSZDKPRPDF-UHFFFAOYSA-N
InChI=1S/C14H20N4O/c1-2-7-18(8-3-1)10-13-11-19-17-14(16-13)12-5-4-6-15-9-12/h4-6,9,13H,1-3,7-8,10-11H2,(H,16,17)
IROXANADINE, a pyridine derivative, is under development for the treatment of atherosclerosis and the complications of atherosclerosis such as ischaemic heart disease, peripheral arterial disease, and restenosis. It induces phosphorylation of p38 stress-activated protein kinase, which plays an important role in endothelial cells (EC) homeostasis. EC function plays a central role in vascular diseases.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Restenosis and therapy. | 2012 |
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| Reverse regulation of endothelial cells and myointimal hyperplasia on cell proliferation by a heatshock protein-coinducer after hypoxia. | 2008-03 |
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| Pharmacological attenuation of apoptosis in reoxygenated endothelial cells. | 2004-12 |
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| Pharmacologically activated migration of aortic endothelial cells is mediated through p38 SAPK. | 2002-06 |
Sample Use Guides
Iroxanadine (BRX-235) may improve survival of vascular endothelial cells (ECs) following ischemia/reperfusion stress. ECs cultured from human umbilical veins were exposed to hypoxia/reoxygenation to mimic ischemia/reperfusion. Caspase activation and apoptosis were monitored in the reoxygenated cells. Addition of BRX-235 (0.1-1 microM) to culture medium prior to hypoxia or at start of reoxygenation significantly reduced the caspase-dependent apoptosis. The cytoprotection conferred by the pre-hypoxic drug administration was sensitive to quercetin and seems to be based on enhanced heat shock protein accumulation in stressed ECs.
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3JD92A4CWW
Created by
admin on Mon Mar 31 22:36:44 GMT 2025 , Edited by admin on Mon Mar 31 22:36:44 GMT 2025
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934838-71-8
Created by
admin on Mon Mar 31 22:36:44 GMT 2025 , Edited by admin on Mon Mar 31 22:36:44 GMT 2025
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