Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C26H36N2O4 |
| Molecular Weight | 440.575 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC=C(C=C1OC)[C@](CCCNCCC2=CC(OC)=C(OC)C=C2)(C#N)C(C)C
InChI
InChIKey=UPKQNCPKPOLASS-AREMUKBSSA-N
InChI=1S/C26H36N2O4/c1-19(2)26(18-27,21-9-11-23(30-4)25(17-21)32-6)13-7-14-28-15-12-20-8-10-22(29-3)24(16-20)31-5/h8-11,16-17,19,28H,7,12-15H2,1-6H3/t26-/m1/s1
Arverapamil (brand name Rezular), a modulator of melatonin and serotonin receptors, was developed by Ireland-based company, AGI Therapeutics. The drug participated in phase III of clinical trials for patients to treat the irritable bowel syndrome with diarrhea, the trial was discontinued because the drug didn’t meet the primary endpoint.
Approval Year
Sample Use Guides
In Vivo Use Guide
Sources: https://clinicaltrials.gov/ct2/show/NCT00552565
Rezular (arverapamil) 37.5mg 3xday up to 12 weeks or Rezular 75mg 3xday up to 12 weeks
Route of Administration:
Oral
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DTXSID601316844
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DB06669
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SUBSTANCE RECORD