GLYCOL SALICYLATE

US Previously Marketed

Details

Stereochemistry	ACHIRAL
Molecular Formula	C9H10O4
Molecular Weight	182.1733
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OCCOC(=O)C1=CC=CC=C1O

InChI

InChIKey=LVYLCBNXHHHPSB-UHFFFAOYSA-N

InChI=1S/C9H10O4/c10-5-6-13-9(12)7-3-1-2-4-8(7)11/h1-4,10-11H,5-6H2

HIDE SMILES / InChI

Description
Sources: http://www.salonpas.sg/products/list003.html
Curator's Comment: Description was created based on several sources, including http://www.genome.jp/dbget-bin/www_bget?dr:D01557

Glycol Salicylate is a nonsteroidal antiinflammatory drug, it is an ingredient of many rubefacient creams and sprays for the relief of aches, pains and stiffness in muscles joints and tendons. It is an analgesic and anti-inflammatory agent, used topically. It is also included in preparations for soothing haemorrhoids. Glycol Salicylate is a component of Salonsip Gel Patch. Salonsip Gel Patch, manufactured by Hisamitsu Pharmaceutical Co., Inc. of Tosu City, Japan, consists of Glycol Salicylate 1.25%, l-menthol 1.00%, Tocopherol Acetate 1.0%, dl-camphor 0.1%.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Muscle pain 7 Sources: http://www.salonpas.sg/products/list003.html	Palliative		Approved 8583	Salonsip Gel-Patch Approved Use For relief of aches, pains and minor inflammations associated with: ■ muscle fatigue ■ muscle pain ■ stiff shoulder ■ simple backache ■ bruises ■ sprains ■ strains ■ arthritis ■ minor frostbite
Tendonitis 6 Sources: http://www.ncbi.nlm.nih.gov/pubmed/22578338	Palliative		Approved 8583	Percutalgine Approved Use For treatment of benign joint conditions such as mild tendinitis, small joint arthritis and sprains.

Doses

Dose	Population	Adverse events
10 % 1 times / day single, topical Studied dose Dose: 10 %, 1 times / day Route: topical Route: single Dose: 10 %, 1 times / day Sources: https://link.springer.com/article/10.2165/00128415-199505760-00023	healthy, 47 years Health Status: healthy Age Group: 47 years Sex: M Sources: https://link.springer.com/article/10.2165/00128415-199505760-00023	Other AEs: Contact dermatitis... Other AEs: Contact dermatitis Sources: https://link.springer.com/article/10.2165/00128415-199505760-00023
5 % multiple, topical Studied dose Dose: 5 % Route: topical Route: multiple Dose: 5 % Sources: https://pubmed.ncbi.nlm.nih.gov/21569750/	unhealthy, 64 years Health Status: unhealthy Age Group: 64 years Sex: M Sources: https://pubmed.ncbi.nlm.nih.gov/21569750/	Other AEs: Contact dermatitis... Other AEs: Contact dermatitis Sources: https://pubmed.ncbi.nlm.nih.gov/21569750/
12.5 mg 5 times / day multiple, topical Studied dose Dose: 12.5 mg, 5 times / day Route: topical Route: multiple Dose: 12.5 mg, 5 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/22110924/	unhealthy, mean age 30.8 years Health Status: unhealthy Age Group: mean age 30.8 years Sex: M+F Sources: https://pubmed.ncbi.nlm.nih.gov/22110924/	Disc. AE: Urticaria, Skin irritation... Other AEs: Redness, Itching... AEs leading to discontinuation/dose reduction: Urticaria (0.4%) Skin irritation (0.4%) Other AEs: Redness (1.7%) Itching (1.7%) Urticaria (1.7%) Sources: https://pubmed.ncbi.nlm.nih.gov/22110924/
12.5 mg 5 times / day multiple, topical Studied dose Dose: 12.5 mg, 5 times / day Route: topical Route: multiple Dose: 12.5 mg, 5 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/22110924/	unhealthy, mean age 30.8 years Health Status: unhealthy Age Group: mean age 30.8 years Sex: M+F Sources: https://pubmed.ncbi.nlm.nih.gov/22110924/	Disc. AE: Urticaria, Redness... AEs leading to discontinuation/dose reduction: Urticaria (0.4%) Redness (0.4%) Allergic reaction (0.4%) Sources: https://pubmed.ncbi.nlm.nih.gov/22110924/

AEs

AE	Significance	Dose	Population
Contact dermatitis		10 % 1 times / day single, topical Studied dose Dose: 10 %, 1 times / day Route: topical Route: single Dose: 10 %, 1 times / day Sources: https://link.springer.com/article/10.2165/00128415-199505760-00023	healthy, 47 years Health Status: healthy Age Group: 47 years Sex: M Sources: https://link.springer.com/article/10.2165/00128415-199505760-00023
Contact dermatitis		5 % multiple, topical Studied dose Dose: 5 % Route: topical Route: multiple Dose: 5 % Sources: https://pubmed.ncbi.nlm.nih.gov/21569750/	unhealthy, 64 years Health Status: unhealthy Age Group: 64 years Sex: M Sources: https://pubmed.ncbi.nlm.nih.gov/21569750/
Skin irritation	0.4% Disc. AE	12.5 mg 5 times / day multiple, topical Studied dose Dose: 12.5 mg, 5 times / day Route: topical Route: multiple Dose: 12.5 mg, 5 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/22110924/	unhealthy, mean age 30.8 years Health Status: unhealthy Age Group: mean age 30.8 years Sex: M+F Sources: https://pubmed.ncbi.nlm.nih.gov/22110924/
Urticaria	0.4% Disc. AE	12.5 mg 5 times / day multiple, topical Studied dose Dose: 12.5 mg, 5 times / day Route: topical Route: multiple Dose: 12.5 mg, 5 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/22110924/	unhealthy, mean age 30.8 years Health Status: unhealthy Age Group: mean age 30.8 years Sex: M+F Sources: https://pubmed.ncbi.nlm.nih.gov/22110924/
Itching	1.7%	12.5 mg 5 times / day multiple, topical Studied dose Dose: 12.5 mg, 5 times / day Route: topical Route: multiple Dose: 12.5 mg, 5 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/22110924/	unhealthy, mean age 30.8 years Health Status: unhealthy Age Group: mean age 30.8 years Sex: M+F Sources: https://pubmed.ncbi.nlm.nih.gov/22110924/
Redness	1.7%	12.5 mg 5 times / day multiple, topical Studied dose Dose: 12.5 mg, 5 times / day Route: topical Route: multiple Dose: 12.5 mg, 5 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/22110924/	unhealthy, mean age 30.8 years Health Status: unhealthy Age Group: mean age 30.8 years Sex: M+F Sources: https://pubmed.ncbi.nlm.nih.gov/22110924/
Urticaria	1.7%	12.5 mg 5 times / day multiple, topical Studied dose Dose: 12.5 mg, 5 times / day Route: topical Route: multiple Dose: 12.5 mg, 5 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/22110924/	unhealthy, mean age 30.8 years Health Status: unhealthy Age Group: mean age 30.8 years Sex: M+F Sources: https://pubmed.ncbi.nlm.nih.gov/22110924/
Allergic reaction	0.4% Disc. AE	12.5 mg 5 times / day multiple, topical Studied dose Dose: 12.5 mg, 5 times / day Route: topical Route: multiple Dose: 12.5 mg, 5 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/22110924/	unhealthy, mean age 30.8 years Health Status: unhealthy Age Group: mean age 30.8 years Sex: M+F Sources: https://pubmed.ncbi.nlm.nih.gov/22110924/
Redness	0.4% Disc. AE	12.5 mg 5 times / day multiple, topical Studied dose Dose: 12.5 mg, 5 times / day Route: topical Route: multiple Dose: 12.5 mg, 5 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/22110924/	unhealthy, mean age 30.8 years Health Status: unhealthy Age Group: mean age 30.8 years Sex: M+F Sources: https://pubmed.ncbi.nlm.nih.gov/22110924/
Urticaria	0.4% Disc. AE	12.5 mg 5 times / day multiple, topical Studied dose Dose: 12.5 mg, 5 times / day Route: topical Route: multiple Dose: 12.5 mg, 5 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/22110924/	unhealthy, mean age 30.8 years Health Status: unhealthy Age Group: mean age 30.8 years Sex: M+F Sources: https://pubmed.ncbi.nlm.nih.gov/22110924/

Sourcing

Vendor/Aggregator	ID	URL
3B Scientific (Wuhan) Corp	3B3-032938	http://www.3bsc.com/index/pro_info.php?id=54202
AA Blocks	AA004LQ3	https://www.aablocks.com/goods/Goods/detail?id=AA004LQ3
Aaron Chemicals	AR004MHV	http://www.aaronchem.com/87-28-5
abcr GmbH	AB135809	http://www.abcr.com/shop/en/AB135809
Acadechem	ACDS-033425	http://www.acadechemical.com/product/108124
Accela ChemBio Inc	SY032913	http://www.accelachem.com/cn/search.html?keyword=SY032913&attname=GoodsCode
Achemica	ACMC-209qjg	http://www.achemica.com/prodinfo/?id=132816
Achemo Scientific Limited	AC-65563	http://www.achemo.com/search/?Keyword=87-28-5
Acros Organics	AC174100010	https://www.fishersci.com/shop/products/2-hydroxyethylesalicylate-acros-organics/AC174100010
Acros Organics	AC174100500	https://www.fishersci.com/shop/products/2-hydroxyethylesalicylate-acros-organics/AC174100500
Acros Organics	AC174102500	https://www.fishersci.com/shop/products/2-hydroxyethylesalicylate-acros-organics/AC174102500
AEchem Scientific Corp., USA	AE020076	http://www.aechemsc.com/info_products/AE020076.php
AHH Chemical co.,ltd	MT-51663	http://www.ahhchemical.com/product/MT-51663.html
AK Scientific, Inc. (AKSCI)	U132	http://www.aksci.com/item_detail.php?cat=U132
Alfa Chemistry	87-28-5	https://www.alfa-chemistry.com/cas_87-28-5.htm
Alichem	19092936	http://www.alichem.com/en/products/87-28-5.html
Anward	ANW-38666	http://www.anward.com/pro_result/7488
BioSynth	W-104034	https://www.biosynth.com/en/products/chemical-intermediates/advanced-intermediates/products/W-104034.html
BLD Pharm	BD129722	http://www.bldpharm.com/products/87-28-5.html
Chem Scene	CS-B1707	http://www.chemscene.com/87-28-5.html
ChemMol	49416923	http://www.chemmol.com/chemmol/49416923.html
Chemspace	CSSB00000229999	https://chem-space.com/CSSB00000229999
eNovation Chemicals	D956881	https://www.enovationchem.com/ProductDetails.asp?ProductID=D956881
Finetech	FT-0626298	http://www.finetechnology-ind.com/prod/detail/pub/87-28-5.html
Glentham Life Sciences	GK0594	http://www.glentham.com/products/product/GK0594/
Hairui	HR138380	http://www.hairuichem.com/en/product/87-28-5.html
iChemical	EBD54184	http://www.ichemical.com/chemicals/cas-87-28-5
Lab Network	LN00225237	https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN00225237
LGC Standards	LGCFOR0112.00	https://www.lgcstandards.com/US/en/p/LGCFOR0112.00
LGC Standards	MM0112.00-0100	https://www.lgcstandards.com/US/en/p/MM0112.00-0100
mcule	MCULE-8684266018	https://mcule.com/MCULE-8684266018/
MedChem Express	HY-B2208	https://www.medchemexpress.com/Glycol_salicylate.html
Oakwood	241853	http://www.oakwoodchemical.com/ProductsList.aspx?CategoryID=-2&txtSearch=122852&ExtHyperLink=1
Sigma-Aldrich	03830_SIAL	https://www.sigmaaldrich.com/catalog/product/sial/03830?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	H1429400_SIAL	https://www.sigmaaldrich.com/catalog/product/sial/h1429400?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sinfoo Biotech	S017768	http://www.sinfoobiotech.com/product/1021166
Smolecule	S006610	http://www.smolecule.com/products/s006610
Smolecule	S748753	https://www.smolecule.com/products/s748753
TCI (Tokyo Chemical Industry)	E0113	http://www.tcichemicals.com/eshop/en/us/commodity/E0113/index.html
THE BioTek	bt-255405	https://www.thebiotek.com/product/inhibitors/bt-255405
VladaChem	VL270628-100G	https://www.vladachem.com/product.php?products=87-28-5

PubMed

Title	Date	PubMed
Synergetic analgesic effect of the combination of arnica and hydroxyethyl salicylate in ethanolic solution following cutaneous application by transcutaneous electrostimulation.	2003	14732966
Contact dermatitis from anti-inflammatory gel containing hydroxyethyl salicylate.	2002-08	12455553

Patents

Sample Use Guides

In Vivo Use Guide

Adults and children 12 years of age and over: clean and dry affected area. Remove from backing film and apply to affected area not more than 3 to 4 times daily. Remove after at most 8 hours.

Route of Administration: Topical

In Vitro Use Guide

Unknown

Name

Type

Language

GLYCOL SALICYLATE

Official Name

English

HYDROXYETHYL SALICYLATE

Preferred Name

English

2-HYDROXYETHYL SALICYLATE

Systematic Name

English

2-HYDROXYETHYL 2-HYDROXYBENZOATE

Systematic Name

English

GLYCOL SALICYLATE [MART.]

Common Name

English

HYDROXYETHYL SALICYLATE [EP MONOGRAPH]

Common Name

English

BENZOIC ACID, 2-HYDROXY-, 2-HYDROXYETHYL ESTER

Common Name

English

NSC-72097

Code

English

Glycol salicylate [WHO-DD]

Common Name

English

SALICYLIC ACID, 2-HYDROXYETHYL ESTER

Common Name

English

GLYCOL SALICYLATE [JAN]

Common Name

English

GLYCOL SALICYLATE [MI]

Common Name

English

Code System Code Type Description

CAS

87-28-5