Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C23H30N2O |
| Molecular Weight | 349.4978 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CN([11CH3])C1(CCCC1)[C@@H](NC(=O)C2=C(C)C=CC=C2C)C3=CC=CC=C3
InChI
InChIKey=BMXRRRIDMAIEKX-SVZFZNDKSA-N
InChI=1S/C23H30N2O/c1-17-11-10-12-18(2)20(17)22(26)24-21(19-13-6-5-7-14-19)23(25(3)4)15-8-9-16-23/h5-7,10-14,21H,8-9,15-16H2,1-4H3,(H,24,26)/t21-/m0/s1/i3-1
Approval Year
| Name | Type | Language | ||
|---|---|---|---|---|
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Common Name | English | ||
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Code | English | ||
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Systematic Name | English | ||
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Systematic Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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1000022-56-9
Created by
admin on Sat Dec 16 11:45:30 GMT 2023 , Edited by admin on Sat Dec 16 11:45:30 GMT 2023
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NON-SPECIFIC STEREOCHEMISTRY | |||
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GSK-931145-(11C)
Created by
admin on Sat Dec 16 11:45:30 GMT 2023 , Edited by admin on Sat Dec 16 11:45:30 GMT 2023
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PRIMARY | ((11)C)GSK931145 showed good brain penetration and a heterogeneous distribution in agreement with reported GlyT1 localization. Following pretreatment with GSK565710, uptake of ((11)C)GSK931145 was reduced to homogeneous levels. Although ((11)C)GSK565710 also showed good brain penetration and a heterogeneous distribution, the apparent level of specific binding was reduced compared to ((11)C)GSK931145. In contrast, ((11)C)GSK991022 showed a much lower brain penetration and resultant signal following pretreatment with GSK565710. Based on these findings ((11)C)GSK931145 was identified as the most promising ligand for imaging GlyT1 in the porcine brain, possessing good brain penetration, specific signal, and reversible kinetics. ((11)C)GSK931145 is now being progressed into higher species. | ||
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44253521
Created by
admin on Sat Dec 16 11:45:30 GMT 2023 , Edited by admin on Sat Dec 16 11:45:30 GMT 2023
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PRIMARY | |||
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3GD8XN4ZNE
Created by
admin on Sat Dec 16 11:45:30 GMT 2023 , Edited by admin on Sat Dec 16 11:45:30 GMT 2023
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PRIMARY |
ACTIVE MOIETY
