| Stereochemistry | ACHIRAL |
| Molecular Formula | C25H33FN2O4 |
| Molecular Weight | 443.5415 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=C(OC)C=C2CN(CCCCNC(=O)C3=C(OCC[18F])C=CC(C)=C3)CCC2=C1
InChI
InChIKey=QVRVXSZKCXFBTE-KPVNRNJOSA-N
InChI=1S/C25H33FN2O4/c1-18-6-7-22(32-13-9-26)21(14-18)25(29)27-10-4-5-11-28-12-8-19-15-23(30-2)24(31-3)16-20(19)17-28/h6-7,14-16H,4-5,8-13,17H2,1-3H3,(H,27,29)/i26-1
ISO-1 F-18 is a benzamide analog radiolabeled with 18F. It is a sigma-2 receptor ligand. Since sigma-2 receptor is expressed in higher density in proliferating tumor cells versus quiescent tumor cells, ISO-1 F-18 can be used as a positron emission tomography (PET) tracer to evaluate tumor proliferation by PET in patients with malignant neoplasms. Currently, ISO-1 F-18 in Phase I clinical trial as an investigational radiotracer in primary breast cancer.
Originator
Approval Year
PubMed
ACTIVE MOIETY
