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Details

Stereochemistry ABSOLUTE
Molecular Formula C12H18N2O5
Molecular Weight 270.2817
Optical Activity UNSPECIFIED
Defined Stereocenters 3 / 3
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of EPERVUDINE

SMILES

CC(C)C1=CN([C@H]2C[C@H](O)[C@@H](CO)O2)C(=O)NC1=O

InChI

InChIKey=PHUUXVYXSRZACJ-IVZWLZJFSA-N
InChI=1S/C12H18N2O5/c1-6(2)7-4-14(12(18)13-11(7)17)10-3-8(16)9(5-15)19-10/h4,6,8-10,15-16H,3,5H2,1-2H3,(H,13,17,18)/t8-,9+,10+/m0/s1

HIDE SMILES / InChI

Description

Epervudine (5-isopropyl-2'-deoxyuridine) is an antiviral compound. The antiviral effect of epervudine on herpes viruses (HSV-1 and HSV-2) is based on the sensitivity of virus DNA to nucleases due to epervudine incorporation into the virus DNA and the resulting change in DNA conformation. Virus selectivity is based on virus induced thymidine kinase activity and on HSV induction of polymerase enzymes catalyzing the incorporation. Epervudine (HEVIZOS) ointment is used to treat herpetic skin infections.

Originator

Approval Year

PubMed

Patents

Sample Use Guides

In Vivo Use Guide
Epervudine (HEVIZOS) 8 mg/g ointment
Route of Administration: Topical