Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C23H32N3O10P.2Na |
| Molecular Weight | 587.4676 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 7 / 7 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].[Na+].CC(C)C[C@H](NP([O-])(=O)O[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O)C(=O)N[C@@H](CC2=CNC3=C2C=CC=C3)C([O-])=O
InChI
InChIKey=OQKHVXFOYFBMDJ-ODIUWQMJSA-L
InChI=1S/C23H34N3O10P.2Na/c1-11(2)8-16(26-37(33,34)36-23-20(29)19(28)18(27)12(3)35-23)21(30)25-17(22(31)32)9-13-10-24-15-7-5-4-6-14(13)15;;/h4-7,10-12,16-20,23-24,27-29H,8-9H2,1-3H3,(H,25,30)(H,31,32)(H2,26,33,34);;/q;2*+1/p-2/t12-,16-,17-,18-,19+,20+,23-;;/m0../s1
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Mechanisms underlying increased release of endothelin-1 from aorta in diabetic rats. | 2001 Apr |
|
| Apparent B-type natriuretic peptide selectivity in the kidney due to differential processing. | 2001 Aug |
|
| Deletion of neutral endopeptidase exacerbates intestinal inflammation induced by Clostridium difficile toxin A. | 2001 Aug |
|
| A proteinase inhibitor decreases tumor growth in a laparoscopic rat model. | 2001 Aug |
|
| Tachykinin NK(3) receptor agonists induced microvascular leakage hypersensitivity in the guinea-pig airways. | 2001 Dec 21 |
|
| The role of substance P release in the lung with esophageal acid. | 2001 Dec 3 |
|
| Chronic tobacco smoke exposure increases airway sensitivity to capsaicin in awake guinea pigs. | 2001 Feb |
|
| Neutral endopeptidase terminates substance P-induced inflammation in allergic contact dermatitis. | 2001 Jan 15 |
|
| Mitogen-activated protein kinase activity regulation role of angiotensin and endothelin systems in vascular smooth muscle cells. | 2001 Jan 5 |
|
| Upregulation of neutral endopeptidase expression and enzymatic activity during the differentiation of human choriocarcinoma cells. | 2001 Jul |
|
| Effect of ECE and NEP inhibition on cigarette smoke-induced cell proliferation in the rat lung. | 2001 Jun |
|
| Tachykinin-induced bronchoconstriction in sheep is NK-1 receptor mediated and exhibits tachyphylaxis. | 2001 Jun |
|
| Soluble CD44 inhibits melanoma tumor growth by blocking cell surface CD44 binding to hyaluronic acid. | 2001 Jun 7 |
|
| Interactions of human matrix metalloproteinase 7 (matrilysin) with the inhibitors thiorphan and R-94138. | 2001 Mar |
|
| Reverse mode of the Na+-Ca2+ exchange after myocardial stretch: underlying mechanism of the slow force response. | 2001 Mar 2 |
|
| Effect of phosphoramidon on brain tissue angiogenesis in the chronic phase of vasospasm after subarachnoid hemorrhage in the rat. | 2001 Nov-Dec |
|
| Differential effects of U46619 on renal regional hemodynamics in the rat: involvement of endothelin. | 2001 Oct |
|
| In vitro contractile effects of neurokinin receptor blockade in the human ureter. | 2001 Oct |
|
| Determination of bradykinin in rat urine by coupled-column high pressure liquid chromatography with precolumn derivatization with a water-soluble fluorogenic reagent. | 2001 Oct 1 |
|
| Substance P induced preprotachykinin-a mRNA, neutral endopeptidase mRNA and substance P in cultured normal fibroblasts. | 2002 Apr |
|
| Induction of apoptosis and CD10/neutral endopeptidase expression by jaspamide in HL-60 line cells. | 2002 Aug |
|
| Tachykinins and airway microvascular leakage induced by HCl intra-oesophageal instillation. | 2002 Aug |
|
| Phosphoramidon treatment improves the consequences of chagasic heart disease in mice. | 2002 Aug |
|
| Expression, purification and characterization of the monomeric and dimeric forms of soluble bovine endothelin converting enzyme-1a. | 2002 Aug |
|
| Characterization of PgPepO, a bacterial homologue of endothelin-converting enzyme-1. | 2002 Aug |
|
| Vascular endothelin converting enzyme-1 expression and activity is upregulated in clinical diabetes. | 2002 Fall |
|
| Neprilysin inhibitors potentiate effects of bradykinin on b2 receptor. | 2002 Feb |
|
| ET(A) and ET(B) receptors modulate the proliferation of human pulmonary artery smooth muscle cells. | 2002 Feb 1 |
|
| Endothelin-1[1-31]: a novel autocrine-paracrine regulator of human adrenal cortex secretion and growth. | 2002 Jan |
|
| Vasospasm following subarachnoid hemorrhage: evidence against functional upregulation of Rho kinase constrictor pathway. | 2002 Jun |
|
| Enhancement of neurokinin A-induced smooth muscle contraction in human urinary bladder by mucosal removal and phosphoramidon: relationship to peptidase inhibition. | 2002 Mar 8 |
|
| Effect of endothelin-converting enzyme inhibitors on big endothelin-1 induced contraction in isolated rat basilar artery. | 2002 Nov |
|
| Extracellular peptidases of imaginal discs of Drosophila melanogaster. | 2002 Nov |
|
| The mechanisms for tachykinin-induced contractions of the rabbit corpus cavernosum. | 2002 Nov |
|
| Cardioprotective effects of phosphoramidon on myocardial structure and function in murine Chagas' disease. | 2002 Nov |
|
| Role of abnormal neutral endopeptidase-like activities in Hyp mouse bone cells in renal phosphate transport. | 2002 Nov |
|
| High-performance liquid chromatographic separation of renin-angiotensin system peptides and most of their metabolic fragments. | 2002 Nov 25 |
|
| [Met5]enkephalin-Arg-Gly-Leu-induced antinociception is greatly increased by peptidase inhibitors. | 2002 Oct 18 |
|
| Mycosin-1, a subtilisin-like serine protease of Mycobacterium tuberculosis, is cell wall-associated and expressed during infection of macrophages. | 2002 Oct 7 |
|
| Bradykinin potentiation by ACE inhibitors: a matter of metabolism. | 2002 Sep |
|
| Cerebral angiogenesis and expression of VEGF after subarachnoid hemorrhage (SAH) in rats. | 2003 Aug 15 |
|
| Essential role for vascular gelatinase activity in relaxin-induced renal vasodilation, hyperfiltration, and reduced myogenic reactivity of small arteries. | 2003 Dec 12 |
|
| Effect of endothelin-1 (1-31) on the renal resistance vessels. | 2003 Feb |
|
| Binding of a new bioactive 31-amino-acid endothelin-1 to an endothelin ET(B) or ET(B)-like receptor in porcine lungs. | 2003 Mar 28 |
|
| Metalloendopeptidase inhibition regulates phosphorylation of p38-mitogen-activated protein kinase and nitric oxide synthase in heart after endotoxemia. | 2003 Oct |
|
| Aminopeptidases function as endocytic receptors in the trophotaenial placenta of the goodeid fish, Ameca splendens (Teleostei: Atheriniformes). | 2003 Oct 1 |
Patents
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Common Name | English | ||
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Common Name | English | ||
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Code | English | ||
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Systematic Name | English | ||
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Systematic Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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16219931
Created by
admin on Sat Dec 16 08:45:56 GMT 2023 , Edited by admin on Sat Dec 16 08:45:56 GMT 2023
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PRIMARY | |||
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DBSALT001879
Created by
admin on Sat Dec 16 08:45:56 GMT 2023 , Edited by admin on Sat Dec 16 08:45:56 GMT 2023
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PRIMARY | |||
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3F7O684NXF
Created by
admin on Sat Dec 16 08:45:56 GMT 2023 , Edited by admin on Sat Dec 16 08:45:56 GMT 2023
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PRIMARY | |||
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164204-38-0
Created by
admin on Sat Dec 16 08:45:56 GMT 2023 , Edited by admin on Sat Dec 16 08:45:56 GMT 2023
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PRIMARY | |||
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DTXSID90657562
Created by
admin on Sat Dec 16 08:45:56 GMT 2023 , Edited by admin on Sat Dec 16 08:45:56 GMT 2023
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PRIMARY | |||
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694280
Created by
admin on Sat Dec 16 08:45:56 GMT 2023 , Edited by admin on Sat Dec 16 08:45:56 GMT 2023
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PRIMARY | |||
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119942-99-3
Created by
admin on Sat Dec 16 08:45:56 GMT 2023 , Edited by admin on Sat Dec 16 08:45:56 GMT 2023
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NON-SPECIFIC STOICHIOMETRY |
PARENT (SALT/SOLVATE)
SUBSTANCE RECORD
