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Details

Stereochemistry ABSOLUTE
Molecular Formula C11H13N3O
Molecular Weight 203.2404
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SUMANIROLE

SMILES

CN[C@H]1CN2C(=O)NC3=C2C(C1)=CC=C3

InChI

InChIKey=RKZSNTNMEFVBDT-MRVPVSSYSA-N
InChI=1S/C11H13N3O/c1-12-8-5-7-3-2-4-9-10(7)14(6-8)11(15)13-9/h2-4,8,12H,5-6H2,1H3,(H,13,15)/t8-/m1/s1

HIDE SMILES / InChI

Description

Sumanirole is a novel dopamine agonist with high affinity and efficacy at D2 dopamine receptors and has a substantial degree of selectivity for the D2 receptor over other dopamine receptor subtypes. It had been in clinical trials for the treatment of Parkinson’s disease and restless leg syndrome but these studies were terminated for the efficacy reason.

CNS Activity

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency
12.0 nM [Ki]
1.9 µM [Ki]
92.0 nM [Ki]

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown
Primary
Unknown

Doses

AEs

PubMed

Sample Use Guides

In Vivo Use Guide
1 to 16 mg/day
Route of Administration: Oral
In Vitro Use Guide
Sumanirole activated D2 receptor-stimulated mitogenesis with an EC50 of 4.6 nM, but it had no activity at D3 and D4 receptors in measurements of receptor-activated mitogenesis at concentrations up to 1 uM.