Stereochemistry | ACHIRAL |
Molecular Formula | C26H28N2 |
Molecular Weight | 368.5139 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 1 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
C(\C=C\C1=CC=CC=C1)N2CCN(CC2)C(C3=CC=CC=C3)C4=CC=CC=C4
InChI
InChIKey=DERZBLKQOCDDDZ-JLHYYAGUSA-N
InChI=1S/C26H28N2/c1-4-11-23(12-5-1)13-10-18-27-19-21-28(22-20-27)26(24-14-6-2-7-15-24)25-16-8-3-9-17-25/h1-17,26H,18-22H2/b13-10+
Cinnarizine is a piperazine derivative with antihistaminic, antiserotonergic, antidopaminergic, and calcium channel-blocking activities. It inhibits calcium translocation across the vestibular sensory cells in the ampullae and maintains endolymph flow by preventing constriction of the stria vascularis. It is currently used for the treatment of nausea, vomiting, and vertigo caused by Meniere’s disease and other vestibular disorders. Cinnarizine is also used for prevention and treatment of motion sickness. Chronic use of cinnarizine may induce extrapyramidal symptoms.
CNS Activity
Originator
Approval Year
Sample Use Guides
Stugeron® 15 mg tablets
Cinnarizine
For travel sickness
Adults and children over 12 years old:
• 2 tablets 2 hours before travelling then
• 1 tablet every 8 hours during the journey
Children aged 5 – 12 years old:
• 1 tablet 2 hours before travelling then
• ½ a tablet every 8 hours during the journey
For problems with balance
Adults and children over 12 years old:
• 2 tablets 3 times a day
Children aged 5-12 years old:
• 1 tablet 3 times a day
Route of Administration:
Oral