U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C20H36N.Cl
Molecular Weight 325.96
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MIRIPIRIUM CHLORIDE

SMILES

[Cl-].CCCCCCCCCCCCCC[N+]1=CC=C(C)C=C1

InChI

InChIKey=ZCTSINFCZHUVLI-UHFFFAOYSA-M
InChI=1S/C20H36N.ClH/c1-3-4-5-6-7-8-9-10-11-12-13-14-17-21-18-15-20(2)16-19-21;/h15-16,18-19H,3-14,17H2,1-2H3;1H/q+1;/p-1

HIDE SMILES / InChI
Miripirium chloride is used as an antimicrobial preservative in some pharmaceutical products. Miripirium was used as the preservative in Depo-Medrol. Miripirium was used as constituent of methylprednisolone acetate suspensions used for intra-articular corticosteroid therapy.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: Hyaluronic acid biosynthesis
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Depo-Medrol

Approved Use

INDICATIONS AND USAGE Musculoskeletal Conditions. As with other adrenal steroids, DEPO-MEDROL Sterile Aqueous Suspension has been found useful in alleviating the pain and lameness associated with acute localized arthritic conditions and generalized arthritic conditions. It has been used successfully to treat rheumatoid arthritis, traumatic arthritis, osteoarthritis, periostitis, tendinitis, synovitis, tenosynovitis, bursitis, and myositis of horses; traumatic arthritis, osteoarthritis, and generalized arthritic conditions of dogs. Allergic Conditions. This preparation is especially beneficial in relieving pruritus and inflammation of allergic dermatitis, acute moist dermatitis, dry eczema, urticaria, bronchial asthma, pollen sensitivities and otitis externa in dogs; allergic dermatitis and moist and dry eczema in cats.Overwhelming Infections with Severe Toxicity. In dogs and cats moribund from overwhelmingly severe infections for which antibacterial therapy is available (eg, critical pneumonia, pyometritis), DEPO-MEDROL may be lifesaving, acting to inhibit the inflammatory reaction, which itself may be lethal; preventing vascular collapse and preserving the integrity of the blood vessels; modifying the patient’s reaction to drugs; and preventing or reducing the exudative reaction which often complicates certain infections. As supportive therapy, it improves the general attitude of the animal being treated.
PubMed

PubMed

TitleDatePubMed
The effects of Depo-Medrol preservative on the rabbit visual system.
1991 Nov
Delayed hypersensitivity reaction to the preservative myristyl picolinium chloride.
1995 Sep
Contact allergy to miripirium chloride in Depo-Medrol.
2001 Feb
Patents

Sample Use Guides

In Vivo Use Guide
Curator's Comment: In rabbits intravitreal injection was used https://www.ncbi.nlm.nih.gov/pubmed/8505218
Rats: determinations of the minimum lethal doses of myristyl-y-picolinium chloride (Miripirium) were made intravenously, intraperitoneally, subcutaneously, and by stomach tube. A lO-mg./ml. solution in physiological saline was used intravenously and intraperitoneally. A 30-mg/ml solution was used subcutaneously and orally. The approximate LDw's of myristyl-7-picolinium chloride are 200 mg/Kg subcutaneously, 7.5 mg/Kg intraperitoneally, 30 mg/Kg intravenously, and 250 mg/Kg by stomach tube.
Route of Administration: Other
In Vitro Use Guide
Unknown
Name Type Language
MIRIPIRIUM CHLORIDE
INN   MART.  
INN  
Official Name English
miripirium chloride [INN]
Common Name English
MYRISTYL-.GAMMA.-PICOLINIUM CHLORIDE [II]
Common Name English
MYRISTYL .GAMMA.-PICOLINIUM CHLORIDE
Common Name English
MIRIPIRIUM CHLORIDE [MART.]
Common Name English
1-TETRADECYL-4-PICOLINIUM CHLORIDE
Common Name English
NSC-36338
Code English
MYRISTYL-.GAMMA.-PICOLINIUM CHLORIDE
II  
Common Name English
PYRIDINIUM, 4-METHYL-1-TETRADECYL-, CHLORIDE (1:1)
Systematic Name English
MYRISTYL-GAMMA-PICOLINIUM CHLORIDE
Common Name English
MIRIPIRIUM CHLORIDE [GREEN BOOK]
Common Name English
Code System Code Type Description
ChEMBL
CHEMBL1393904
Created by admin on Sat Dec 16 16:52:29 GMT 2023 , Edited by admin on Sat Dec 16 16:52:29 GMT 2023
PRIMARY
PUBCHEM
17671
Created by admin on Sat Dec 16 16:52:29 GMT 2023 , Edited by admin on Sat Dec 16 16:52:29 GMT 2023
PRIMARY
EVMPD
SUB08991MIG
Created by admin on Sat Dec 16 16:52:29 GMT 2023 , Edited by admin on Sat Dec 16 16:52:29 GMT 2023
PRIMARY
SMS_ID
100000080665
Created by admin on Sat Dec 16 16:52:29 GMT 2023 , Edited by admin on Sat Dec 16 16:52:29 GMT 2023
PRIMARY
DAILYMED
3D6CWI0P23
Created by admin on Sat Dec 16 16:52:29 GMT 2023 , Edited by admin on Sat Dec 16 16:52:29 GMT 2023
PRIMARY
CAS
2748-88-1
Created by admin on Sat Dec 16 16:52:29 GMT 2023 , Edited by admin on Sat Dec 16 16:52:29 GMT 2023
PRIMARY
EPA CompTox
DTXSID2046834
Created by admin on Sat Dec 16 16:52:29 GMT 2023 , Edited by admin on Sat Dec 16 16:52:29 GMT 2023
PRIMARY
NSC
36338
Created by admin on Sat Dec 16 16:52:29 GMT 2023 , Edited by admin on Sat Dec 16 16:52:29 GMT 2023
PRIMARY
ECHA (EC/EINECS)
220-387-1
Created by admin on Sat Dec 16 16:52:29 GMT 2023 , Edited by admin on Sat Dec 16 16:52:29 GMT 2023
PRIMARY
FDA UNII
3D6CWI0P23
Created by admin on Sat Dec 16 16:52:29 GMT 2023 , Edited by admin on Sat Dec 16 16:52:29 GMT 2023
PRIMARY
INN
6585
Created by admin on Sat Dec 16 16:52:29 GMT 2023 , Edited by admin on Sat Dec 16 16:52:29 GMT 2023
PRIMARY
NCI_THESAURUS
C166671
Created by admin on Sat Dec 16 16:52:29 GMT 2023 , Edited by admin on Sat Dec 16 16:52:29 GMT 2023
PRIMARY