EFLUMAST

Details

Stereochemistry	ACHIRAL
Molecular Formula	C10H8FN5O3
Molecular Weight	265.2006
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(=O)C1=CC(F)=CC(NC(=O)C2=NN=NN2)=C1O

InChI

InChIKey=BKAPZKSRERAYQD-UHFFFAOYSA-N

InChI=1S/C10H8FN5O3/c1-4(17)6-2-5(11)3-7(8(6)18)12-10(19)9-13-15-16-14-9/h2-3,18H,1H3,(H,12,19)(H,13,14,15,16)

HIDE SMILES / InChI

Description
Sources: https://adisinsight.springer.com/drugs/800000053 | https://www.ncbi.nlm.nih.gov/pubmed/2870188

Eflumast (RP42068; N-(2-hydroxy-3-acetyl-5-fluorophenyl)-5-carboxamido-1H tetrazole) is an antiallergic agent. It was under development as an orally active antiasthmatic.

Originator

Approval Year

PubMed

Title	Date	PubMed
Synthesis and quantitative structure-activity relationships of antiallergic 2-hydroxy-N-1H-tetrazol-5-ylbenzamides and N-(2-hydroxyphenyl)-1H-tetrazole-5-carboxamides.	1986 Apr	2870188
The validation of a radioimmunoassay for the quantification of eflumast in clinical samples.	1992 Feb-Mar	1391104

Name

Type

Language

EFLUMAST

Official Name

English

3'-ACETYL-5'-FLUORO-2'-HYDROXY-1H-TETRAZOLE-5-CARBOXANILIDE

Systematic Name

English

eflumast [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29578