Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C29H51N5O4 |
| Molecular Weight | 533.7463 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 3 / 3 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CNCC(=O)N[C@H](C(=O)N[C@@H](CC1=CC=CC=C1)[C@H](O)CN(CCC(C)C)C(=O)NC(C)(C)C)C(C)(C)C
InChI
InChIKey=ICOKEKQSBZSLIB-JBRSBNLGSA-N
InChI=1S/C29H51N5O4/c1-20(2)15-16-34(27(38)33-29(6,7)8)19-23(35)22(17-21-13-11-10-12-14-21)31-26(37)25(28(3,4)5)32-24(36)18-30-9/h10-14,20,22-23,25,30,35H,15-19H2,1-9H3,(H,31,37)(H,32,36)(H,33,38)/t22-,23+,25+/m0/s1
Droxinavir is hydroxyethylurea human immunodeficiency virus type 1 (HIV-1) protease inhibitor. Position 88 of HIV-1 protease gene plays a key role in the interaction between droxinavir and the protease molecule. A mutation in this position, located outside the active site, confers resistance to the hydroxyethylurea inhibitor droxinavir. The V82A and N88S substitutions conferred droxinavir resistance on HIV-1 recombinant variants. Positions 82 and 88 are reported to be variable in natural populations isolated from patients who have not been treated with protease inhibitors. Droxinavir had been in preclinical phase for the treatment of HIV-1 infection. However, this study was discontinued.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Protease inhibitors: where are they now? | 1995 Jan |
|
| A mutation in human immunodeficiency virus type 1 protease at position 88, located outside the active site, confers resistance to the hydroxyethylurea inhibitor SC-55389A. | 1997 Mar |
|
| Estimate of the frequency of human immunodeficiency virus type 1 protease inhibitor resistance within unselected virus populations in vitro. | 1998 Feb |
| Name | Type | Language | ||
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| Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C97366
Created by
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| Code System | Code | Type | Description | ||
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Droxinavir
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100000081011
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DTXSID30166769
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7412
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CHEMBL2110878
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465403
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3CF21QCB9J
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SUB06421MIG
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159910-86-8
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C73145
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PRIMARY |
ACTIVE MOIETY
SALT/SOLVATE (PARENT)
