Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C7H9N3.2ClH |
| Molecular Weight | 208.088 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.Cl.NC(=N)C1=CC=C(N)C=C1
InChI
InChIKey=GHEHNICLPWTXJC-UHFFFAOYSA-N
InChI=1S/C7H9N3.2ClH/c8-6-3-1-5(2-4-6)7(9)10;;/h1-4H,8H2,(H3,9,10);2*1H
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Natural and synthetic inhibitors of kallikrein-related peptidases (KLKs). | 2010-11 |
|
| dsDNA-triggered energy transfer and lanthanide sensitization processes. Luminescent probing of specific A/T sequences. | 2010-08-14 |
|
| Trypsin-like serine proteases in Lutzomyia longipalpis--expression, activity and possible modulation by Leishmania infantum chagasi. | 2010-05-18 |
|
| Conversion of trypsin to a copper enzyme: tyrosinase/catechol oxidase by chemical modification. | 2010 |
|
| Molecular basis of thrombomodulin activation of slow thrombin. | 2009-10 |
|
| Purification and partial characterization of a myofibril-bound serine protease from ostrich skeletal muscle. | 2009-10 |
|
| Activation loop 3 and the 170 loop interact in the active conformation of coagulation factor VIIa. | 2009-06 |
|
| An earthworm protease cleaving serum fibronectin and decreasing HBeAg in HepG2.2.15 cells. | 2008-11-24 |
|
| Functional role of residue 193 (chymotrypsin numbering) in serine proteases: influence of side chain length and beta-branching on the catalytic activity of blood coagulation factor XIa. | 2008-02-05 |
|
| Neutralization of plasminogen activator inhibitor I (PAI-1) by the synthetic antagonist PAI-749 via a dual mechanism of action. | 2007-10 |
|
| Macromolecular substrate-binding exosites on both the heavy and light chains of factor XIa mediate the formation of the Michaelis complex required for factor IX-activation. | 2007-08-28 |
|
| Cell surface-bound plasminogen regulates hepatocyte proliferation through a uPA-dependent mechanism. | 2007-06 |
|
| Novel biomimetic affinity ligands for human tissue plasminogen activator. | 2007-04-13 |
|
| A cross-reactive material positive variant of coagulation factor XI (FXIP520L) with a catalytic defect. | 2007-04 |
|
| Eisenia fetida protease-III-1 functions in both fibrinolysis and fibrogenesis. | 2007 |
|
| Biological fingerprinting analysis of the interactome of a kinase inhibitor in human plasma by a chemiproteomic approach. | 2006-11-17 |
|
| Superparamagnetic poly(methyl methacrylate) beads for nattokinase purification from fermentation broth. | 2006-09 |
|
| High resolution structures of p-aminobenzamidine- and benzamidine-VIIa/soluble tissue factor: unpredicted conformation of the 192-193 peptide bond and mapping of Ca2+, Mg2+, Na+, and Zn2+ sites in factor VIIa. | 2006-08-25 |
|
| Recovery of urokinase from integrated mammalian cell culture cryogel bioreactor and purification of the enzyme using p-aminobenzamidine affinity chromatography. | 2006-06-09 |
|
| Amplification of the urokinase gene and the sensitivity of prostate cancer cells to urokinase inhibitors. | 2006-02 |
|
| A urokinase-type plasminogen activator-inhibiting cyclic peptide with an unusual P2 residue and an extended protease binding surface demonstrates new modalities for enzyme inhibition. | 2005-11-18 |
|
| Shedding of the germinal angiotensin I-converting enzyme (gACE) involves a serine protease and is activated by epididymal fluid. | 2005-11 |
|
| Mutagenesis studies toward understanding the mechanism of the cofactor function of thrombomodulin. | 2005-10-03 |
|
| Na+ site in blood coagulation factor IXa: effect on catalysis and factor VIIIa binding. | 2005-07-01 |
|
| Exosite-mediated substrate recognition of factor IX by factor XIa. The factor XIa heavy chain is required for initial recognition of factor IX. | 2005-06-24 |
|
| Quantitative determination of the ligand content in Benzamidine Sepharose 4 Fast Flow media with ion-pair chromatography. | 2005-04-08 |
|
| Degradation of berenil (diminazene aceturate) in acidic aqueous solution. | 2004-10 |
|
| Structural role of Gly(193) in serine proteases: investigations of a G555E (GLY193 in chymotrypsin) mutant of blood coagulation factor XI. | 2004-07-09 |
|
| Augmented intrinsic activity of Factor VIIa by replacement of residues 305, 314, 337 and 374: evidence of two unique mutational mechanisms of activity enhancement. | 2004-04-15 |
|
| Zymogenic and enzymatic properties of the 70-80 loop mutants of factor X/Xa. | 2004-02 |
|
| Potent bivalent inhibition of human tryptase-beta by a synthetic inhibitor. | 2003-12 |
|
| Characterization of p-aminobenzamidine-based sorbent and its use for high-performance affinity chromatography of trypsin-like proteases. | 2003-08-15 |
|
| Increased migration of murine keratinocytes under hypoxia is mediated by induction of urokinase plasminogen activator. | 2002-12 |
|
| Clonidine displacement from type 1 imidazoline receptor by p-aminobenzamidine, the prototype of trypsin-like serine protease inhibitors. | 2002-11 |
|
| Thermodynamic linkage between the S1 site, the Na+ site, and the Ca2+ site in the protease domain of human activated protein C (APC). Sodium ion in the APC crystal structure is coordinated to four carbonyl groups from two separate loops. | 2002-08-09 |
|
| 4-Aminoarylguanidine and 4-aminobenzamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors. | 2002-08-05 |
|
| Kinetic analysis of a unique direct prothrombinase, fgl2, and identification of a serine residue critical for the prothrombinase activity. | 2002-05-15 |
|
| The catalytic domain of endogenous urokinase-type plasminogen activator is required for the mitogenic activity of platelet-derived and basic fibroblast growth factors in human vascular smooth muscle cells. | 2002-05-01 |
|
| Inhibition of urokinase-type plasminogen activator delays expression of c-jun, activated transforming growth factor beta 1, and matrix metalloproteinase 2 during post-hepatectomy liver regeneration in mice. | 2002-05 |
|
| A functional comparison of ovine and porcine trypsins. | 2002-03 |
|
| Purification and characterization of an extracellular trypsin-like protease of Fusarium oxysporum var. lini. | 2002 |
|
| Linear competitive inhibition of human tissue kallikrein by 4-aminobenzamidine and benzamidine and linear mixed inhibition by 4-nitroaniline and aniline. | 2001-01 |
|
| Inhibition of pig liver and Zea mays L. polyamine oxidase: a comparative study. | 2001 |
|
| [Synthetic inhibitors of serine proteinases. Part 26: Inhibition of trypsin, plasmin and thrombin by amides of N alpha-arylsulfonylated 2-amino-4-(4-amidino-phenyl) butyric acid and 2-amino-5-amidinophenyl valeric acids (author's transl)]. | 1982-04 |
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DTXSID10179695
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219-692-2
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3C7VNU62AG
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56418
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75626
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2498-50-2
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SUBSTANCE RECORD
