Pegorgotein (formerly known as PEG-SOD) was developed by Enzon pharmaceutical as a scavenger of oxygen-derived free radicals. This drug under the trade name DISMUTEC participated in phase III clinical trial in patients with a severe closed head injury. It was found that the drug failed to show a statistically significant difference between the treatment group and the control group. In spite of DISMUTEC exhibited longer circulating half-life and reduced immunogenicity; however, the drug showed insufficient therapeutic effect for this indication. In addition, pegorgotein was studied for patients with reperfusion injury and stroke. However, these studies were also discontinued.
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PubMed
| Title | Date | PubMed |
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| Arsenic and chromium in drinking water promote tumorigenesis in a mouse colitis-associated colorectal cancer model and the potential mechanism is ROS-mediated Wnt/β-catenin signaling pathway. | 2012-07-01 |
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| Angiotensin II induces oxidative stress in prostate cancer. | 2008-02 |
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| Redox regulation of HIF-1alpha levels and HO-1 expression in renal medullary interstitial cells. | 2003-06 |
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