MOXADOLEN

Details

Stereochemistry	RACEMIC
Molecular Formula	C11H13NO4
Molecular Weight	223.2252
Optical Activity	( + / - )
Defined Stereocenters	5 / 5
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12C[C@@]([H])(C=C1)[C@]3([H])C(=O)O[C@@H](OC(=O)NC)[C@]23[H]

InChI

InChIKey=ZMXUEEVRCMPQPF-UTABRTIASA-N

InChI=1S/C11H13NO4/c1-12-11(14)16-10-8-6-3-2-5(4-6)7(8)9(13)15-10/h2-3,5-8,10H,4H2,1H3,(H,12,14)/t5-,6+,7+,8-,10+/m1/s1

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Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3382460 | https://www.ncbi.nlm.nih.gov/pubmed/3370074 | https://www.ncbi.nlm.nih.gov/pubmed/3389981

Moxadolen is tricyclo-[5.2.1.0.2.6endo]decenone derivative. Moxadolen pharmacokinetics were investigated after oral application in male Wistar rats. The compound is extensively absorbed and mainly renally eliminated. Within 60 h, 63% of the activity is recovered in urine and feces. After 12 h 27% of the activity is eliminated (application in polyethylene glycol). The highest total concentration of the activity in the plasma is found after 2 h, the highest of the unchanged drug is found after 1 h. The half-life is 2.9 h.

Originator

Approval Year

PubMed

Title	Date	PubMed
[Pharmacokinetics of 4-oxa-5-exo-(N-methylcarbamoyloxy)-tricyclo- [5.2.1.0. 2,6-endo] dec-8-en-3-one in the rat].	1988 Mar	3382460

Patents

Name

Type

Language

MOXADOLEN

Official Name

English

moxadolen [INN]

Common Name

English

METHYLCARBAMIC ACID, ESTER WITH (3R*,3AR*,4S*,7R*,7AS*)-3A,4,7,7A-TETRAHYDRO-3-HYDROXY-4,7-METHANOISOBENZOFURAN-1(3H)-ONE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C241