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Details

Stereochemistry ABSOLUTE
Molecular Formula C27H48O6
Molecular Weight 468.6664
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of NOBIPROSTOLAN

SMILES

CCCCCCCC2(CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C\CCCC(=O)OC(C)C)OCCO2

InChI

InChIKey=FCDDMESBMCWDJP-PEEJLGBMSA-N
InChI=1S/C27H48O6/c1-4-5-6-9-12-16-27(31-18-19-32-27)17-15-23-22(24(28)20-25(23)29)13-10-7-8-11-14-26(30)33-21(2)3/h7,10,21-25,28-29H,4-6,8-9,11-20H2,1-3H3/b10-7+/t22-,23-,24+,25-/m1/s1

HIDE SMILES / InChI
Mallinckrodt (previously Sucampo Pharmaceuticals) is developing nobiprostolan (RK 023), a topical therapy for male pattern baldness (androgenetic alopecia) and hypotrichosis. The drug is a physiologically active fatty acid derivative. Nobiprostolan is in Phase IIa clinical trials for the treatment of male pattern baldness.

Approval Year

Sample Use Guides

RK-023 was applied 2 mL each to a hair-thinning part of scalp twice daily in the patients with androgenetic alopecia.
Route of Administration: Topical
Name Type Language
NOBIPROSTOLAN
INN  
INN  
Official Name English
13,14-DIHYDRO-15,15-ETHYLENEDIOXY-20-ETHYL-PG F2.ALPHA. ISOPROPYL ESTER
Common Name English
5-HEPTENOIC ACID, 7-(2-(2-(2-HEPTYL-1,3-DIOXOLAN-2-YL)ETHYL)-3,5-DIHYDROXYCYCLOPENTYL)-, 1-METHYLETHYL ESTER, (1R-(1.ALPHA.(Z),2.BETA.,3.ALPHA.,5.ALPHA.))-
Common Name English
nobiprostolan [INN]
Common Name English
PROPAN-2-YL (5E)-7-((1R,2R,3R,5S)-2-(2-(2-HEPTYL-1,3-DIOXOLAN-2-YL)ETHYL)-3,5-DIHYDROXYCYCLOPENTYL(HEPT-5-ENOATE
Systematic Name English
Code System Code Type Description
NCI_THESAURUS
C166664
Created by admin on Sat Dec 16 07:53:13 GMT 2023 , Edited by admin on Sat Dec 16 07:53:13 GMT 2023
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PUBCHEM
11719714
Created by admin on Sat Dec 16 07:53:13 GMT 2023 , Edited by admin on Sat Dec 16 07:53:13 GMT 2023
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FDA UNII
3AF610ZQ3R
Created by admin on Sat Dec 16 07:53:13 GMT 2023 , Edited by admin on Sat Dec 16 07:53:13 GMT 2023
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SMS_ID
300000037032
Created by admin on Sat Dec 16 07:53:13 GMT 2023 , Edited by admin on Sat Dec 16 07:53:13 GMT 2023
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INN
9690
Created by admin on Sat Dec 16 07:53:13 GMT 2023 , Edited by admin on Sat Dec 16 07:53:13 GMT 2023
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CAS
120373-67-3
Created by admin on Sat Dec 16 07:53:13 GMT 2023 , Edited by admin on Sat Dec 16 07:53:13 GMT 2023
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