Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C23H28O12 |
| Molecular Weight | 496.4612 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 11 / 11 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]12C[C@@]4(O[C@]3([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@]1(COC(=O)C5=CC=C(O)C=C5)[C@@]6([H])O[C@]2(O)C[C@]4(C)O6
InChI
InChIKey=FCHVXNVDFYXLIL-WRJNSLSBSA-N
InChI=1S/C23H28O12/c1-20-8-22(30)13-6-23(20,33-18-16(28)15(27)14(26)12(7-24)32-18)21(13,19(34-20)35-22)9-31-17(29)10-2-4-11(25)5-3-10/h2-5,12-16,18-19,24-28,30H,6-9H2,1H3/t12-,13-,14-,15+,16-,18+,19-,20+,21+,22-,23+/m1/s1
Oxypaeoniflorin is a natural product derived from Radix Paeoniae Rubra and Radix Paeoniae Alba. Oxypaeoniflora had protective effects on AGEs-induced mesangial
cell damage. The pretreatment with oxypaeoniflora (10-8-10-4 M) significantly increased advanced glycation end product-induced glutathione peroxidase and catalase activities in mesangial cells HBZY-1. Oxypaeniflora attenuated markedly advanced glycation end products-induced inflammation cytokines interleukin-6 and monocyte chemoattractant protein-1 levels in ELISA and western blot analysis in a dose-dependent manner. Oxypaeniflora was able to attenuate advanced glycation end products-induced oxidative damage and inflammation in mesangial cells. Oxypaeniflora might therefore have a beneficial effect in the treatment of diabetic nephropathy.
Approval Year
Sample Use Guides
Rats: Aqueous solutions of Radix Paeoniae Rubra and Radix Paeoniae
Alba were given to rats at a dose of containing 0.2 g/g crude drug. After dosing for 5, 10, 15, 20, 30, 60, 90, 120, 180, 240, 360, 540 min,
0.2 ml venous blood samples were collected in 1.5 ml heparinized
tubes by eye puncture. Oxypaeoniflorin is a component of extracts of Radix Paeoniae Rubra and Radix Paeoniae Alba. After oral gavage of
Radix Paeoniae Rubra and Radix Paeoniae Alba at the same amount
of crude drug, the content of oxypaeoniflorin in plasma reached
themaximum at 0.33 ± 0.06 h and 0.67 ± 0.23 h, respectively, which
showed great significance.
Route of Administration:
Oral
The pretreatment with
Oxypaeoniflora (10−6, 10−5, 10−4 M) also decreased seriously the macrophage
migration to 0.19 ± 0.05, 0.15 ± 0.03, and 0.14 ± 0.02, respectively,
in a dose-dependent manner. The pretreatment with
Oxypaeoniflora (10−5–10−4 M) could significantly inhibit the
level of MCP-1. The IC50 values of paeoniflorin and oxypaeoniflora for inhibiting 2,2'-azinobis-(3-thylbenzothiazoline-6-sulfonic acid) formation were 4.197 × 10-4 M and 1.002 × 10-4 M, respectively.
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3A7O4NBD5S
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SUBSTANCE RECORD
