DISOPHENOL

Details

Stereochemistry	ACHIRAL
Molecular Formula	C6H3I2NO3
Molecular Weight	390.9019
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC1=C(I)C=C(C=C1I)[N+]([O-])=O

InChI

InChIKey=UVGTXNPVQOQFQW-UHFFFAOYSA-N

InChI=1S/C6H3I2NO3/c7-4-1-3(9(11)12)2-5(8)6(4)10/h1-2,10H

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/588311 | https://www.gpo.gov/fdsys/pkg/CFR-1996-title21-vol6/pdf/CFR-1996-title21-vol6-sec522-740.pdf

Disophenol is a drug used in veterinary medicine recommended for use in the treatment of dogs infested with hook worms (Ancylostoma caninum, A. braziliense and Uncinuriu stenocephala) and cats infested with the hookworm A. tubaeforme.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Ancylostoma caninum 2 Target ID: Ancylostoma caninum Sources: https://www.gpo.gov/fdsys/pkg/CFR-1996-title21-vol6/pdf/CFR-1996-title21-vol6-sec522-740.pdf	Inhibitor 8297
Uncinaria stenocephala 2 Target ID: Uncinaria stenocephala Sources: https://www.gpo.gov/fdsys/pkg/CFR-1996-title21-vol6/pdf/CFR-1996-title21-vol6-sec522-740.pdf	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Helminthiasis 39 Sources: https://www.gpo.gov/fdsys/pkg/CFR-1996-title21-vol6/pdf/CFR-1996-title21-vol6-sec522-740.pdf https://www.ncbi.nlm.nih.gov/pubmed/5730548 https://www.ncbi.nlm.nih.gov/pubmed/14008172	Curative		Approved 8429	ANCYLOL Approved Use The drug is used for the treatment of both dogs infested with hookworms (including Ancylostoma caninum, A. braziliense and Uncinaria stenocephala) and cats infested with the hookworm A. tubaeforme. Launch Date 1964

PubMed

Title	Date	PubMed
2,6-Diiodo-4-nitrophenol, 2,6-diiodo-4-nitrophenyl acetate and 2,6-diiodo-4-nitroanisole: interplay of hydrogen bonds, iodo-nitro interactions and aromatic pi-pi-stacking interactions to give supramolecular structures in one, two and three dimensions.	2002 Aug	12154300

Patents

Sample Use Guides

In Vivo Use Guide

Dogs and cats: Disophenol is administered subcutaneously at a dosage level equivalent to 4.5 milligrams of disophenol per pound of body weight. A second treatment may be indicated 21 days after the initial treatment.

Route of Administration: Other

In Vitro Use Guide

Disophenol produced contracture of the rat cardiac muscle at concentrations of 100 and 1000 ng/ml and at the latter dose diastolic tension after 60 min perfusion was approximately 300 per cent of its initial value.

Name

Type

Language

DISOPHENOL

Common Name

English

DISOPHEN

Brand Name

English

ANCYLOL

Brand Name

English

SYNGAMIX

Brand Name

English

IODOFEN

Brand Name

English

PHENOL, 2,6-DIIODO-4-NITRO-

Systematic Name

English

DISOFEN

Brand Name

English

DISOPHENOL [MART.]

Common Name

English

NSC-94733

Code

English

DISOPHENOL [MI]

Common Name

English

2,6-DIIODO-4-NITROPHENOL

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C250