MK-8617

Details

Stereochemistry	ACHIRAL
Molecular Formula	C24H21N5O4
Molecular Weight	443.4546
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC=C(C=C1)C(NC(=O)C2=CN=C(NC2=O)C3=CC=CN=N3)C4=CC=C(OC)C=C4

InChI

InChIKey=WXLPERVDMILVIF-UHFFFAOYSA-N

InChI=1S/C24H21N5O4/c1-32-17-9-5-15(6-10-17)21(16-7-11-18(33-2)12-8-16)27-23(30)19-14-25-22(28-24(19)31)20-4-3-13-26-29-20/h3-14,21H,1-2H3,(H,27,30)(H,25,28,31)

HIDE SMILES / InChI

Approval Year

Targets

Primary Target	Pharmacology	Potency
Egl nine homolog 2 7 Target ID: Q96KS0 Gene ID: 112398.0 Gene Symbol: EGLN2 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/28002958	Inhibitor 8504	1.0 nM [IC50]
Egl nine homolog 1 15 Target ID: Q9GZT9 Gene ID: 54583.0 Gene Symbol: EGLN1 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/28002958	Inhibitor 8504	1.0 nM [IC50]
Egl nine homolog 3 13 Target ID: Q9H6Z9 Gene ID: 112399.0 Gene Symbol: EGLN3 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/28002958	Inhibitor 8504	14.0 nM [IC50]

Name

Type

Language

5-PYRIMIDINECARBOXAMIDE, N-(BIS(4-METHOXYPHENYL)METHYL)-1,6-DIHYDRO-6-OXO-2-(3-PYRIDAZINYL)-

Preferred Name

English

MK-8617

Code

English

Code System Code Type Description

PUBCHEM

44230662

Created by admin on Mon Mar 31 23:01:09 GMT 2025 , Edited by admin on Mon Mar 31 23:01:09 GMT 2025

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FDA UNII

39RRC0G27V

Created by admin on Mon Mar 31 23:01:09 GMT 2025 , Edited by admin on Mon Mar 31 23:01:09 GMT 2025

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SMS_ID

300000041468

Created by admin on Mon Mar 31 23:01:09 GMT 2025 , Edited by admin on Mon Mar 31 23:01:09 GMT 2025

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CAS

1187990-87-9

Created by admin on Mon Mar 31 23:01:09 GMT 2025 , Edited by admin on Mon Mar 31 23:01:09 GMT 2025

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ACTIVE MOIETY


					39RRC0G27V

MK-8617