U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C25H24N2O4S
Molecular Weight 448.534
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PAMICOGREL

SMILES

CCOC(=O)CN1C=CC=C1C2=NC(=C(S2)C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4

InChI

InChIKey=ISCHOARKJADAKJ-UHFFFAOYSA-N
InChI=1S/C25H24N2O4S/c1-4-31-22(28)16-27-15-5-6-21(27)25-26-23(17-7-11-19(29-2)12-8-17)24(32-25)18-9-13-20(30-3)14-10-18/h5-15H,4,16H2,1-3H3

HIDE SMILES / InChI

Description
Curator's Comment: Description was created based on several sources, including http://link.springer.com/article/10.2165%2F00128413-200112720-00021 and http://www.ncbi.nlm.nih.gov/pubmed/9013200

Pamicogrel is a cyclooxygenase inhibitor with platelet anti-aggregatory properties which is under development by Kanebo for chronic arterial occlusion. It also has potential in both prophylaxis and treatment of ischemic brain injury. An NDA was submitted in Japan in April 1997. The effects of the drug on platelet aggregation were originally disclosed in EP-00159677, while the later European patent, EP-00560136, claims its use in brain dysfunction induced by hypoxia arising from disturbance of cerebral circulation, such as cerebral hemorrhage or cerebral infarction.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Determination of the antiplatelet agent. KB-3022, and its metabolite by high-performance liquid chromatography.
1990 Apr
[Determination of the main metabolite (desethyl KBT-3022) of a new antiplatelet agent, KBT-3022 in plasma by gas chromatography].
1992 Jun
Photo-stability of the new antiplatelet agent, KBT-3022 (ethyl 2-[4,5-bis(4-methoxyphenyl)thiazole-2-yl]pyrrol-1-ylacetate) in aqueous solutions containing acetonitrile.
1992 Nov
The effects of KBT-3022, a new anti-platelet agent, on hemorheological properties in guinea pigs.
1995 Jan
Anti-thrombotic activity of KBT-3022 in experimental models of thrombosis.
1995 Jun
Patents

Sample Use Guides

5 mg once daily was administered orally for 6 weeks.
Route of Administration: Oral
In Vitro Use Guide
Pamicogrel (1 uM) significantly inhibited both neutrophil migration and the increase in [Ca2+] induced by leukotriene B4 (LTB4) in Japanese albino rabbits.
Name Type Language
PAMICOGREL
INN   JAN   MI  
INN  
Official Name English
PAMICOGREL [JAN]
Common Name English
pamicogrel [INN]
Common Name English
KBT3022
Code English
KB3022
Code English
PAMICOGREL [MI]
Common Name English
KBT-3022
Code English
KB-3022
Code English
ETHYL 2-(4,5-BIS(P-METHOXYPHENYL)-2-THIAZOLYL)PYRROLE-1-ACETATE
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C1323
Created by admin on Sat Dec 16 17:06:20 GMT 2023 , Edited by admin on Sat Dec 16 17:06:20 GMT 2023
NCI_THESAURUS C1327
Created by admin on Sat Dec 16 17:06:20 GMT 2023 , Edited by admin on Sat Dec 16 17:06:20 GMT 2023
Code System Code Type Description
EVMPD
SUB09597MIG
Created by admin on Sat Dec 16 17:06:20 GMT 2023 , Edited by admin on Sat Dec 16 17:06:20 GMT 2023
PRIMARY
ChEMBL
CHEMBL2104947
Created by admin on Sat Dec 16 17:06:20 GMT 2023 , Edited by admin on Sat Dec 16 17:06:20 GMT 2023
PRIMARY
CAS
101001-34-7
Created by admin on Sat Dec 16 17:06:20 GMT 2023 , Edited by admin on Sat Dec 16 17:06:20 GMT 2023
PRIMARY
FDA UNII
398FD8EDAL
Created by admin on Sat Dec 16 17:06:20 GMT 2023 , Edited by admin on Sat Dec 16 17:06:20 GMT 2023
PRIMARY
EPA CompTox
DTXSID4048804
Created by admin on Sat Dec 16 17:06:20 GMT 2023 , Edited by admin on Sat Dec 16 17:06:20 GMT 2023
PRIMARY
INN
7174
Created by admin on Sat Dec 16 17:06:20 GMT 2023 , Edited by admin on Sat Dec 16 17:06:20 GMT 2023
PRIMARY
MERCK INDEX
m8373
Created by admin on Sat Dec 16 17:06:20 GMT 2023 , Edited by admin on Sat Dec 16 17:06:20 GMT 2023
PRIMARY Merck Index
WIKIPEDIA
Pamicogrel
Created by admin on Sat Dec 16 17:06:20 GMT 2023 , Edited by admin on Sat Dec 16 17:06:20 GMT 2023
PRIMARY
PUBCHEM
65870
Created by admin on Sat Dec 16 17:06:20 GMT 2023 , Edited by admin on Sat Dec 16 17:06:20 GMT 2023
PRIMARY
SMS_ID
100000082764
Created by admin on Sat Dec 16 17:06:20 GMT 2023 , Edited by admin on Sat Dec 16 17:06:20 GMT 2023
PRIMARY
NCI_THESAURUS
C66300
Created by admin on Sat Dec 16 17:06:20 GMT 2023 , Edited by admin on Sat Dec 16 17:06:20 GMT 2023
PRIMARY