Details
Stereochemistry | RACEMIC |
Molecular Formula | C23H16O6.2C21H27NO |
Molecular Weight | 1007.2599 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 2 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(COC1=CC=CC=C1CC2=CC=CC=C2)N3CCCCC3.CC(COC4=CC=CC=C4CC5=CC=CC=C5)N6CCCCC6.OC(=O)C7=CC8=C(C=CC=C8)C(CC9=C%10C=CC=CC%10=CC(C(O)=O)=C9O)=C7O
InChI
InChIKey=VSVBMXAKSJDLCL-UHFFFAOYSA-N
InChI=1S/C23H16O6.2C21H27NO/c24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29;2*1-18(22-14-8-3-9-15-22)17-23-21-13-7-6-12-20(21)16-19-10-4-2-5-11-19/h1-10,24-25H,11H2,(H,26,27)(H,28,29);2*2,4-7,10-13,18H,3,8-9,14-17H2,1H3
DescriptionSources: http://www.mims.com/hongkong/drug/info/cofrelCurator's Comment: Description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/16297353 and http://www.ncbi.nlm.nih.gov/pubmed/5301345
Sources: http://www.mims.com/hongkong/drug/info/cofrel
Curator's Comment: Description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/16297353 and http://www.ncbi.nlm.nih.gov/pubmed/5301345
Benproperine (Cofrel) is a cough suppressant. It is used for symptomatic relief of cough. Cofrel is 2-4 times as potent as codeine in suppressing cough in animals. It acts peripherally by blocking afferent sensory nerve impulses originating from receptors in the lungs and pleura.
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
Identification of some benproperine metabolites in humans and investigation of their antitussive effect. | 2005 Dec |
|
Identification and quantitative determination of benproperine metabolites in human plasma and urine by liquid chromatography-tandem mass spectrometry. | 2006 Jan 2 |
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[Nondestructive quantitative analysis of Cofrel medicines by improved partial least squares-NIR spectroscopy]. | 2007 Jun |
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Resonance light scattering study on the interaction of benproperine phosphate with eriochrome blue black R in the presence of sodium dodecylbenzene sulphonate and its analytical application. | 2009 Mar-Apr |
Patents
Sample Use Guides
1 or 2 tablets 3 times daily, according to severity of cough. Tablets should be swallowed whole and not chewed.
Route of Administration:
Oral
In Vitro Use Guide
Sources: http://www.ncbi.nlm.nih.gov/pubmed/5301345
10(-5) g/ml of Benproperine (ASA 158/5) caused remarkable reduction of the contraction of the tracheal muscle preparation of a guinea pig caused
by histamine HCl.
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64238-92-2
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91663270
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236750
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370C8CB2K3
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264-745-5
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SUB00704MIG
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m2321
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100000084997
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ACTIVE MOIETY
SUBSTANCE RECORD