PIFEXOLE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C13H8ClN3O
Molecular Weight	257.675
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

ClC1=C(C=CC=C1)C2=NC(=NO2)C3=CC=NC=C3

InChI

InChIKey=YXVGPSQAIBDQJD-UHFFFAOYSA-N

InChI=1S/C13H8ClN3O/c14-11-4-2-1-3-10(11)13-16-12(17-18-13)9-5-7-15-8-6-9/h1-8H

HIDE SMILES / InChI

Description
Sources: Elks, J. (2014) The Dictionary of Drugs: Chemical Data, page 979, retrieved from: https://books.google.ru/books?id=0vXTBwAAQBAJ | Negwer, M., Scharnow, H.-G. (2001) Organic-chemical drugs and their synonyms, page 774, retrieved from: https://books.google.ru/books?id=zGpqAAAAMAAJ | Burger, A., Wolff, M.E. (1981) Burger's Medicinal Chemistry, page 478, retrieved from: https://books.google.ru/books?id=2b3wAAAAMAAJ

Pixefole is the 1,2,4-oxadiazole derivative. It has a similar profile of muscle-relaxant activity in animals to that of chlorzoxazone. In rats, pifexole is reported to be seven times more potent than chlorzoxazone in inhibition of strychnine-induced convulsions.

Approval Year

PubMed

Title	Date	PubMed
Expanding Synthesizable Space of Disubstituted 1,2,4-Oxadiazoles.	2016-10-10	27548754

Name

Type

Language

NSC-305743

Preferred Name

English

PIFEXOLE

Official Name

English

4-(5-(O-CHLOROPHENYL)-1,2,4-OXADIAZOL-3-YL)PYRIDINE

Common Name

English

RI-64

Code

English

pifexole [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29696