Details
Stereochemistry | ACHIRAL |
Molecular Formula | C10H14N2O |
Molecular Weight | 178.231 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCN(CC)C(=O)C1=CN=CC=C1
InChI
InChIKey=NCYVXEGFNDZQCU-UHFFFAOYSA-N
InChI=1S/C10H14N2O/c1-3-12(4-2)10(13)9-6-5-7-11-8-9/h5-8H,3-4H2,1-2H3
DescriptionSources: https://www.rlsnet.ru/mnn_index_id_730.htm
Sources: https://www.rlsnet.ru/mnn_index_id_730.htm
Nikethamide is a respiratory and circulatory stimulant with some central nervous system activity. Widely known by its former trade name of Coramine, it was used in the mid-twentieth century as a medical countermeasure against tranquilizer overdoses, before the advent of endotracheal intubation and positive-pressure lung expansion. Nikethamide is available as a short-acting over-the-counter drug in several South American and European countries, combined with glucose in form of lozenges. Nikethamide is especially useful for mountain climbers to increase endurance at high altitudes. Contraindications include hypertension, cardiovascular pathologies, and epilepsy. In some sports, nikethamide is listed by the World Anti-Doping Agency as a banned substance. Croatian tennis player Marin Čilić was suspended from competition for nine months after he tested positive for nikethamide in April 2013
CNS Activity
Approval Year
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Sources: https://www.rlsnet.ru/mnn_index_id_730.htm |
Primary | Coramine Approved UseUnknown |
PubMed
Title | Date | PubMed |
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Origin of the disjunct tetraploid Cardamine amporitana (Brassicaceae) assessed with nuclear and chloroplast DNA sequence data. | 2004 Aug |
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The role of serendipity in drug discovery. | 2006 |
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The difference between simple and complex leaves. | 2006 Aug |
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The genetic basis for differences in leaf form between Arabidopsis thaliana and its wild relative Cardamine hirsuta. | 2006 Aug |
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Antioxidant activity of wild plants collected in Valsesia, an alpine region of Northern Italy. | 2006 Jul |
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Simultaneous determination of nikethamide and lidocaine in human blood and cerebrospinal fluid by high performance liquid chromatography. | 2007 Apr 11 |
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Hydrotropic polymeric micelles for enhanced paclitaxel solubility: in vitro and in vivo characterization. | 2007 Jan |
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Hybridization between two polyploid Cardamine (Brassicaceae) species in North-western Spain: discordance between morphological and genetic variation patterns. | 2007 Jun |
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Interactions among genes in the ErbB-Neuregulin signalling network are associated with increased susceptibility to schizophrenia. | 2007 Jun 28 |
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Butterfly seed predation: effects of landscape characteristics, plant ploidy level and population structure. | 2007 May |
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Impact of foliar herbivory on the development of a root-feeding insect and its parasitoid. | 2007 May |
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The correct interpretation and lectotypification of the name Cardamine fallax (Brassicaceae). | 2007 Sep |
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[Role of 5-HT(2A) receptor in increase in respiratory-related rhythmic discharge activity by nikethamide in neonatal rat transverse medullary slices]. | 2008 Apr 25 |
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Diaquabis(4-bromo-benzoato-κO)-bis(N,N'-diethyl-nicotinamide-κN)zinc(II). | 2008 Aug 30 |
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A conserved molecular framework for compound leaf development. | 2008 Dec 19 |
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A cross-species transcriptomics approach to identify genes involved in leaf development. | 2008 Dec 5 |
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Diaqua-bis(4-chloro-benzoato-κO)bis-(N,N-diethyl-nicotinamide-κN)manganese(II). | 2008 Feb 29 |
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Mental state decoding v. mental state reasoning as a mediator between cognitive and social function in psychosis. | 2008 Jul |
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Consistent geographic structure among multiple nuclear sequences and cpDNA polymorphisms of Cardamine nipponica Franch. et Savat. (Brassicaceae). | 2008 Jul |
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[GABA A receptor participates in respiratory enhancement induced by nikethamide in neonatal rats]. | 2008 Mar |
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Diaqua-bis(2-chloro-benzoato-κO)bis-(N,N-diethyl-nicotinamide-κN)manganese(II). | 2009 Apr 10 |
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Diaqua-bis(2-bromo-benzoato-κO)bis-(N,N-diethyl-nicotinamide-κN)manganese(II). | 2009 Apr 18 |
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Diaqua-bis(2-bromo-benzoato-κO)bis-(N,N-diethyl-nicotinamide-κN)zinc(II). | 2009 Apr 2 |
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Diaqua-bis(2-chloro-benzoato-κO)bis-(N,N-diethyl-nicotinamide-κN)nickel(II). | 2009 Apr 22 |
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Diaqua-bis-(N,N-diethyl-nicotinamide-κN)bis[4-(dimethyl-amino)-benzoato-κO]cobalt(II). | 2009 Aug 8 |
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Molecular cloning and characterization of a KCS gene from Cardamine graeca and its heterologous expression in Brassica oilseeds to engineer high nervonic acid oils for potential medical and industrial use. | 2009 Dec |
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Increased D-amino acid oxidase expression in the bilateral hippocampal CA4 of schizophrenic patients: a post-mortem study. | 2009 Dec |
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Diaqua-bis(N,N-diethyl-nicotinamide-κN)bis-(4-formyl-benzoato-κO)nickel(II). | 2009 Feb 25 |
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Diaqua-bis(N,N-diethyl-nicotinamide-κN)bis-(4-formyl-benzoato-κO)manganese(II). | 2009 Feb 25 |
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Tetra-kis[μ-4-(diethyl-amino)benzoato-κO:O']bis-[(N,N-diethyl-nicotinamide-κN)zinc(II)]. | 2009 Jul 18 |
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Diaqua-bis(N,N-diethyl-nicotinamide-κN)bis-[4-(dimethyl-amino)benzoato-κO]nickel(II). | 2009 Jul 31 |
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Evidence for the association of the DAOA (G72) gene with schizophrenia and bipolar disorder but not for the association of the DAO gene with schizophrenia. | 2009 Jul 8 |
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Molecular evolution of phytochromes in Cardamine nipponica (Brassicaceae) suggests the involvement of PHYE in local adaptation. | 2009 Jun |
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Diaqua-bis(2-bromo-benzoato-κO)bis-(N,N-diethyl-nicotinamide-κN)nickel(II). | 2009 Jun 13 |
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Comparison of light harvesting and resource allocation strategies between two rhizomatous herbaceous species inhabiting deciduous forests. | 2009 Mar |
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Diaqua-bis(N,N-diethyl-nicotinamide-κN)bis-(4-formyl-benzoato-κO)cobalt(II). | 2009 Mar 11 |
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Tetra-kis[μ-4-(dimethyl-amino)benzoato-κO:O']bis-[(N,N-diethyl-nicotinamide-κN)zinc(II)]. | 2009 Nov 14 |
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Tetra-kis[μ-4-(methyl-amino)-benzoato-κO:O']bis-[(N,N-diethyl-nicotinamide-N)zinc(II)] dihydrate. | 2009 Oct 10 |
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Diaqua-bis(N,N-diethyl-nicotinamide-κN)bis-(4-methyl-benzoato-κO)cobalt(II). | 2010 Apr 21 |
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Diaqua-bis-(2-bromo-benzoato-κO)bis-(N,N-diethyl-nicotinamide-κN)cobalt(II). | 2010 Aug 18 |
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Leaf and floral parts feeding by orange tip butterfly larvae depends on larval position but not on glucosinolate profile or nitrogen level. | 2010 Dec |
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Epidemiological analysis of doping offences in the professional tennis circuit. | 2010 Dec 15 |
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Tetra-kis[μ-4-(diethyl-amino)-benzoato-κO:O']bis-[(N,N-diethyl-nicotinamide-κN)cobalt(II)]. | 2010 Dec 4 |
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Cytotype diversity and genome size variation in eastern Asian polyploid Cardamine (Brassicaceae) species. | 2010 Feb |
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Weeds of change: Cardamine hirsuta as a new model system for studying dissected leaf development. | 2010 Jan |
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Differentiating Arabidopsis shoots from leaves by combined YABBY activities. | 2010 Jul |
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Novel antagonistic interactions associated with plant polyploidization influence trait selection and habitat preference. | 2010 Mar |
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Tetra-kis(μ-4-methyl-benzoato-κO:O')bis-[(N,N-diethyl-nicotinamide-κN)zinc(II)]. | 2010 Mar 31 |
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Evolution of diversity in Albugo is driven by high host specificity and multiple speciation events on closely related Brassicaceae. | 2010 Nov |
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Isolation and structure elucidation of 5'-O-beta-D-glucopyranosyl-dihydroascorbigen from Cardamine diphylla rhizome. | 2010 Sep 3 |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: https://www.rlsnet.ru/tn_index_id_4630.htm
administered to adults in a dose of 1-2 ml 1-3 times a day, children under the skin - 0.1-0.75 ml
Route of Administration:
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WHO-ATC |
R07AB02
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WHO-VATC |
QR07AB02
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NCI_THESAURUS |
C47795
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WHO-ATC |
R07AB52
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C76625
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NIKETHAMIDE
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ACTIVE MOIETY
METABOLITE (PARENT)