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Details

Stereochemistry ABSOLUTE
Molecular Formula C20H24N2O3
Molecular Weight 340.4162
Optical Activity UNSPECIFIED
Defined Stereocenters 5 / 5
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of YOHIMBIC ACID

SMILES

[H][C@@]12CC[C@H](O)[C@H](C(O)=O)[C@@]1([H])C[C@]3([H])N(CCC4=C3NC5=C4C=CC=C5)C2

InChI

InChIKey=AADVZSXPNRLYLV-GKMXPDSGSA-N
InChI=1S/C20H24N2O3/c23-17-6-5-11-10-22-8-7-13-12-3-1-2-4-15(12)21-19(13)16(22)9-14(11)18(17)20(24)25/h1-4,11,14,16-18,21,23H,5-10H2,(H,24,25)/t11-,14-,16-,17-,18+/m0/s1

HIDE SMILES / InChI

Description

Yohimbinic acid, also known as yohimbic acid is an indole alkaloid, which was isolated from dried roots of Rauwolfia serpentina. Yohimbinic acid is a potent inhibitor of a human DNA Topoisomerase I and can inhibit cancer cells growth.

Approval Year

Unknown
139,594

Targets

Primary TargetPharmacologyConditionPotency
DNA topoisomerase 1
16
Inhibitor
8,297
 30.0 µM [IC50]

Conditions

ConditionModalityTargetsHighest PhaseProduct

PubMed

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Compounds 4 (yohimbinic acid) inhibited human promyelocytic leukemia (HL-60) cell growth with IC50 = 84 uM.
ACTIVE MOIETY
Structure of YOHIMBIC ACID
NIH
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