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Details

Stereochemistry ACHIRAL
Molecular Formula C25H37N5O3
Molecular Weight 455.593
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FELCISETRAG

SMILES

COC(=O)N1CCC(CN2CCC(CNC(=O)C3=C4NC(=NC4=CC=C3)C(C)C)CC2)CC1

InChI

InChIKey=MZOITCJKGUIQEI-UHFFFAOYSA-N
InChI=1S/C25H37N5O3/c1-17(2)23-27-21-6-4-5-20(22(21)28-23)24(31)26-15-18-7-11-29(12-8-18)16-19-9-13-30(14-10-19)25(32)33-3/h4-6,17-19H,7-16H2,1-3H3,(H,26,31)(H,27,28)

HIDE SMILES / InChI
TD 8954 (also known as TAK 954) is a selective serotonin 5-HT(4) receptor agonist. It is known a potential role for potent and efficacious 5-HT(4) receptor agonists in the treatment of Alzheimer's disease (AD). TD 8954 participated in phase I clinical trials to study its potential role in the treatment of AD. However, this study was discontinued. In addition, TD 8954 is involved in phase II clinical trials to investigate its effect on gastrointestinal and colonic transit in diabetic or idiopathic gastroparesis participants and for the prophylaxis and treatment of postoperative gastrointestinal dysfunction in participants undergoing large- and small-bowel resection.

Approval Year

PubMed

PubMed

TitleDatePubMed
Participation of 5-HT3, 5-HT4, and nicotinic receptors in the peristaltic reflex of guinea pig distal colon.
1996 Nov
Signal transduction pathways for serotonin as an intestinal secretagogue.
1997 Oct
Serotonin: a mediator of the brain-gut connection.
2000 Oct
Rationale for using serotonergic agents to treat irritable bowel syndrome.
2005 Apr 1
The serotonin signaling system: from basic understanding to drug development for functional GI disorders.
2007 Jan
The Pharmacology of TD-8954, a Potent and Selective 5-HT(4) Receptor Agonist with Gastrointestinal Prokinetic Properties.
2011
Discovery of TD-8954, a clinical stage 5-HT(4) receptor agonist with gastrointestinal prokinetic properties.
2013 Jul 15
Patents

Sample Use Guides

TAK-954 0.1; 0.3; 1 milligram (mg), 60-minute infusion, intravenous (IV), once daily for up to 3 days.
Route of Administration: Intravenous
Name Type Language
FELCISETRAG
USAN   INN  
Official Name English
TAK-954
Code English
1-PIPERIDINECARBOXYLIC ACID, 4-((4-((((2-(1-METHYLETHYL)-1H-BENZIMIDAZOL-7-YL)CARBONYL)AMINO)METHYL)-1-PIPERIDINYL)METHYL)-, METHYL ESTER
Systematic Name English
THRX-149699
Code English
felcisetrag [INN]
Common Name English
METHYL 4-((4-((2-(PROPAN-2-YL)-1H-BENZIMIDAZOLE-4- CARBOXAMIDO)METHYL)PIPERIDIN-1-YL)METHYL)PIPERIDINE-1-CARBOXYLATE
Systematic Name English
TD-8954
Code English
FELCISETRAG [USAN]
Common Name English
Code System Code Type Description
DRUG BANK
DB12725
Created by admin on Sat Dec 16 18:17:57 GMT 2023 , Edited by admin on Sat Dec 16 18:17:57 GMT 2023
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NCI_THESAURUS
C171900
Created by admin on Sat Dec 16 18:17:57 GMT 2023 , Edited by admin on Sat Dec 16 18:17:57 GMT 2023
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CAS
916075-84-8
Created by admin on Sat Dec 16 18:17:57 GMT 2023 , Edited by admin on Sat Dec 16 18:17:57 GMT 2023
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PUBCHEM
11961293
Created by admin on Sat Dec 16 18:17:57 GMT 2023 , Edited by admin on Sat Dec 16 18:17:57 GMT 2023
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USAN
JK-21
Created by admin on Sat Dec 16 18:17:57 GMT 2023 , Edited by admin on Sat Dec 16 18:17:57 GMT 2023
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SMS_ID
300000038048
Created by admin on Sat Dec 16 18:17:57 GMT 2023 , Edited by admin on Sat Dec 16 18:17:57 GMT 2023
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INN
11124
Created by admin on Sat Dec 16 18:17:57 GMT 2023 , Edited by admin on Sat Dec 16 18:17:57 GMT 2023
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FDA UNII
35F0Y2W16Q
Created by admin on Sat Dec 16 18:17:57 GMT 2023 , Edited by admin on Sat Dec 16 18:17:57 GMT 2023
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