Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C29H37N3O3 |
Molecular Weight | 475.6224 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CN(C)CCN(C)[C@H]1COC2=CC=CC=C2C3=C(C4CCCCC4)C5=C(C=C(C=C5)C(O)=O)N3C1
InChI
InChIKey=YQUCBFIQSJVCOR-JOCHJYFZSA-N
InChI=1S/C29H37N3O3/c1-30(2)15-16-31(3)22-18-32-25-17-21(29(33)34)13-14-23(25)27(20-9-5-4-6-10-20)28(32)24-11-7-8-12-26(24)35-19-22/h7-8,11-14,17,20,22H,4-6,9-10,15-16,18-19H2,1-3H3,(H,33,34)/t22-/m1/s1
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/21141896
Sources: https://www.ncbi.nlm.nih.gov/pubmed/21141896
MK-3281 is a potent and orally bioavailable inhibitor of HCV NS5B polymerase which combined excellent cell-based potency with good pharmacokinetic properties in preclinical species. MK-3281 was efficacious in the chimeric mouse model of HCV infection.
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
Discovery of (7R)-14-cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic acid (MK-3281), a potent and orally bioavailable finger-loop inhibitor of the hepatitis C virus NS5B polymerase. | 2011 Jan 13 |
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In vitro efficacy of approved and experimental antivirals against novel genotype 3 hepatitis C virus subgenomic replicons. | 2013 Nov |
Patents
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3593C180JO
Created by
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DTXSID00237197
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886041-60-7
Created by
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100000175842
Created by
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49800096
Created by
admin on Sat Dec 16 11:26:08 GMT 2023 , Edited by admin on Sat Dec 16 11:26:08 GMT 2023
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ACTIVE MOIETY