U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C12H22O11
Molecular Weight 342.2965
Optical Activity UNSPECIFIED
Defined Stereocenters 9 / 9
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of EPILACTOSE

SMILES

[H][C@@](O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O)([C@H](O)CO)[C@H](O)[C@H](O)C=O

InChI

InChIKey=DKXNBNKWCZZMJT-QMRWEYQWSA-N
InChI=1S/C12H22O11/c13-1-4(16)7(18)11(5(17)2-14)23-12-10(21)9(20)8(19)6(3-15)22-12/h1,4-12,14-21H,2-3H2/t4-,5-,6-,7-,8+,9+,10-,11-,12+/m1/s1

HIDE SMILES / InChI
Epilactose (4-O-beta-galactopyranosyl-D-mannnose) is a rare disaccharide in cow milk that can be synthesized from lactose by the cellobiose 2-epimerase of Ruminococcus albus. Epilactose is a promising prebiotic. Dietary supplementation with epilactose (4.5%) increased cecal wall weight and cecal contents and decreased the pH of the cecal contents in Wistar-ST rats. The number of total anaerobes tended to be greater in rats fed epilactose than in those fed the control diet. Epilactose inhibited the conversion of primary bile acids to secondary bile acids. Epilactose also increased the calcium absorption in everted small intestinal sacs. In addition, the levels of plasma total cholesterol and nonhigh-density lipoprotein cholesterol were lower in epilactose-fed rats. These results indicate that epilactose promotes calcium absorption in the small intestine and possibly lowers the risk of arteriosclerosis.

Approval Year

Sample Use Guides

50 g/kg diets for 30 days
Route of Administration: Oral
Name Type Language
EPILACTOSE
II   USP-RS  
Common Name English
EPILACTOSE [II]
Common Name English
4-O-.BETA.-D-GALACTOPYRANOSYL-D-MANNOSE
Common Name English
EPILACTOSE [USP-RS]
Common Name English
LACTULOSE IMPURITY A [EP IMPURITY]
Common Name English
GALBETA-1-4-MAN
Common Name English
Code System Code Type Description
CAS
20869-27-6
Created by admin on Fri Dec 15 15:41:56 GMT 2023 , Edited by admin on Fri Dec 15 15:41:56 GMT 2023
PRIMARY
PUBCHEM
128037
Created by admin on Fri Dec 15 15:41:56 GMT 2023 , Edited by admin on Fri Dec 15 15:41:56 GMT 2023
PRIMARY
CAS
50468-56-9
Created by admin on Fri Dec 15 15:41:56 GMT 2023 , Edited by admin on Fri Dec 15 15:41:56 GMT 2023
ALTERNATIVE
FDA UNII
3515BNP809
Created by admin on Fri Dec 15 15:41:56 GMT 2023 , Edited by admin on Fri Dec 15 15:41:56 GMT 2023
PRIMARY
SMS_ID
100000090145
Created by admin on Fri Dec 15 15:41:56 GMT 2023 , Edited by admin on Fri Dec 15 15:41:56 GMT 2023
PRIMARY
EVMPD
SUB26691
Created by admin on Fri Dec 15 15:41:56 GMT 2023 , Edited by admin on Fri Dec 15 15:41:56 GMT 2023
PRIMARY
MESH
C047464
Created by admin on Fri Dec 15 15:41:56 GMT 2023 , Edited by admin on Fri Dec 15 15:41:56 GMT 2023
PRIMARY
RS_ITEM_NUM
1236801
Created by admin on Fri Dec 15 15:41:56 GMT 2023 , Edited by admin on Fri Dec 15 15:41:56 GMT 2023
PRIMARY