FARGLITAZAR

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C34H30N2O5
Molecular Weight	546.6124
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=C(CCOC2=CC=C(C[C@H](NC3=CC=CC=C3C(=O)C4=CC=CC=C4)C(O)=O)C=C2)N=C(O1)C5=CC=CC=C5

InChI

InChIKey=ZZCHHVUQYRMYLW-HKBQPEDESA-N

InChI=1S/C34H30N2O5/c1-23-29(36-33(41-23)26-12-6-3-7-13-26)20-21-40-27-18-16-24(17-19-27)22-31(34(38)39)35-30-15-9-8-14-28(30)32(37)25-10-4-2-5-11-25/h2-19,31,35H,20-22H2,1H3,(H,38,39)/t31-/m0/s1

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Description
Sources: https://adisinsight.springer.com/drugs/800008802 | https://www.ncbi.nlm.nih.gov/pubmed/26633022 | https://www.ncbi.nlm.nih.gov/pubmed/20444603

Farglitazar is a non-thiazolidinedione insulin sensitizer and agonist of peroxisome proliferator-activated receptor-gamma. GlaxoSmithKline was developing farglitazar for the treatment of liver fibrosis and Type 2 diabetes mellitus.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Peroxisome proliferator-activated receptor gamma 111 Target ID: P37231\|\|\|Q15179 Gene ID: 5468.0 Gene Symbol: PPARG Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/26633022 \| https://www.ncbi.nlm.nih.gov/pubmed/20444603	Agonist 2678

PubMed

Title	Date	PubMed
Synthesis of a high-affinity fluorescent PPARgamma ligand for high-throughput fluorescence polarization assays.	2003 Oct 1	13129568
Novel PPARgamma agonists GI 262570, GW 7845, GW 1929, and pioglitazone decrease calcium channel function and myogenic tone in rat mesenteric arteries.	2005 Jan	15452359

Name

Type

Language

FARGLITAZAR

Official Name

English

Farglitazar [WHO-DD]

Common Name

English

GI-262570X

Code

English

N-(O-BENZOYLPHENYL)-O-(2-(5-METHYL-2-PHENYL-4-OXAZOLYL)ETHYL)-L-TYROSINE

Common Name

English

farglitazar [INN]

Common Name

English

GI-262570

Code

English

L-TYROSINE, N-(2-BENZOYLPHENYL)-O-(2-(5-METHYL-2-PHENYL-4-OXAZOLYL)ETHYL)-

Systematic Name

English

GI262570X

Code

English

G1-262570

Code

English

FARGLITAZAR [USAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C98233