CYTARABINE HYDROCHLORIDE

First approved in 1969

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C9H13N3O5.ClH
Molecular Weight	279.678
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](CO)[C@@H](O)[C@@H]2O

InChI

InChIKey=KCURWTAZOZXKSJ-JBMRGDGGSA-N

InChI=1S/C9H13N3O5.ClH/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8;/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16);1H/t4-,6-,7+,8-;/m1./s1

HIDE SMILES / InChI

Description
Sources: www.accessdata.fda.gov/drugsatfda_docs/label/2011/021041s023lbl.pdf
Curator's Comment: Description was created using several sources including: http://www.ebi.ac.uk/chebi/searchId.do?chebiId=28680 http://www.tandfonline.com/doi/abs/10.1517/17425247.2010.527330

Cytarabine is a pyrimidine nucleoside analog. Cytarabine or cytosine arabinoside (Cytosar-U or Depocyt) is a chemotherapy agent used mainly in the treatment of cancers of white blood cells such as acute myeloid leukemia (AML) and non-Hodgkin lymphoma. It also has antiviral and immunosuppressant properties. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. It is a cell cycle phase-specific, affecting cells only during the S phase of cell division. Intracellularly, cytarabine is converted into cytarabine-5-triphosphate (ara-CTP), which is the active metabolite. The mechanism of action is not completely understood, but it appears that ara-CTP acts primarily through inhibition of DNA polymerase. Incorporation into DNA and RNA may also contribute to cytarabine cytotoxicity. Cytarabine is cytotoxic to a wide variety of proliferating mammalian cells in culture.The drug has a short plasma half-life, low stability and limited bioavailability. Overdosing of patients with continuous infusions may lead to side effects. Thus, various prodrug strategies and delivery systems have been explored extensively to enhance the half-life, stability and delivery of cytarabine. Alternative, delivery systems of cytarabine have emerged for the treatment of different cancers. The liposomal-cytarabine formulation has been approved for the treatment of lymphomatous meningitis.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
DNA polymerase lambda 4 Target ID: CHEMBL5367 Sources: http://www.drugbank.ca/drugs/DB00987	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Chronic myelogenous leukemia 22 Sources: https://clinicaltrials.gov/ct2/show/NCT00333840	Primary		Phase III 656	Unknown Approved Use Unknown
Lymphomatous meningitis 3 Sources: www.accessdata.fda.gov/drugsatfda_docs/label/2011/021041s023lbl.pdf	Primary		Approved 8429	CYTARABINE Approved Use Cytarabine in combination with other approved anticancer drugs is indicated for remission induction in acute non-lymphocytic leukemia of adults and children. It has also been found useful in the treatment of acute lymphocytic leukemia and the blast phase of chronic myelocytic leukemia. Intrathecal administration of cytarabine injection (preservative-free only) is indicated for the prophylaxis and treatment of meningeal leukemia. Launch Date 1969

C_max

Value	Dose	Co-administered	Analyte	Population
62.2 μg/mL DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209401s000lbl.pdf	100 mg/m² 1 times / day multiple, intravenous dose: 100 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered: DAUNORUBICIN	DAUNORUBICIN	CYTARABINE plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN

AUC

Value	Dose	Co-administered	Analyte	Population
1900 μg × h/mL DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209401s000lbl.pdf	100 mg/m² 1 times / day multiple, intravenous dose: 100 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered: DAUNORUBICIN	DAUNORUBICIN	CYTARABINE plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN

T_1/2

Value	Dose	Co-administered	Analyte	Population
40.4 h DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209401s000lbl.pdf	100 mg/m² 1 times / day multiple, intravenous dose: 100 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered: DAUNORUBICIN	DAUNORUBICIN	CYTARABINE plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN
80 h REVIEW https://www.ncbi.nlm.nih.gov/pubmed/12162758	50 mg single, intrathecal dose: 50 mg route of administration: Intrathecal experiment type: SINGLE co-administered:		CYTARABINE unknown	Homo sapiens population: UNKNOWN age: ADULT sex: UNKNOWN food status: UNKNOWN

Doses

Dose	Population	Adverse events
4.5 g/m2 2 times / day multiple, intravenous Highest studied dose Dose: 4.5 g/m2, 2 times / day Route: intravenous Route: multiple Dose: 4.5 g/m2, 2 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/6223674 Page: p.363, 366	unhealthy, 16-76 n = 6 Health Status: unhealthy Condition: Acute leukemia Age Group: 16-76 Sex: M+F Population Size: 6 Sources: https://pubmed.ncbi.nlm.nih.gov/6223674 Page: p.363, 366	Disc. AE: Cerebellar disorder NOS, Diarrhea... AEs leading to discontinuation/dose reduction: Cerebellar disorder NOS (grade 4, 66.7%) Diarrhea (grade 3, 66.7%) Sources: https://pubmed.ncbi.nlm.nih.gov/6223674 Page: p.363, 366
4.5 g/m2 2 times / day multiple, intravenous Highest studied dose Dose: 4.5 g/m2, 2 times / day Route: intravenous Route: multiple Dose: 4.5 g/m2, 2 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/7306918 Page: p.2578	unhealthy, 16-76 n = 6 Health Status: unhealthy Condition: Acute leukemia Age Group: 16-76 Sex: M+F Population Size: 6 Sources: https://pubmed.ncbi.nlm.nih.gov/7306918 Page: p.2578	Disc. AE: Cerebellar disorder NOS, Cerebellar disorder NOS... AEs leading to discontinuation/dose reduction: Cerebellar disorder NOS (grade 4, 33.3%) Cerebellar disorder NOS (grade 5, 16.7%) Sources: https://pubmed.ncbi.nlm.nih.gov/7306918 Page: p.2578
3 g/m2 2 times / day multiple, intravenous MTD Dose: 3 g/m2, 2 times / day Route: intravenous Route: multiple Dose: 3 g/m2, 2 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/6223674 Page: p.366	unhealthy, 16-76 n = 27 Health Status: unhealthy Condition: Acute leukemia Age Group: 16-76 Sex: M+F Population Size: 27 Sources: https://pubmed.ncbi.nlm.nih.gov/6223674 Page: p.366	Sources: https://pubmed.ncbi.nlm.nih.gov/6223674 Page: p.366
100 mg/m2 1 times / day multiple, intravenous Recommended Dose: 100 mg/m2, 1 times / day Route: intravenous Route: multiple Dose: 100 mg/m2, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/071868s032lbl.pdf Page: p.1	unhealthy Health Status: unhealthy Condition: Acute non-lymphocytic leukemia Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/071868s032lbl.pdf Page: p.1	Disc. AE: Bone marrow depression, Leukopenia... AEs leading to discontinuation/dose reduction: Bone marrow depression Leukopenia Thrombocytopenia Anemia Nausea Vomiting Diarrhea Abdominal pain Oral ulceration Hepatic dysfunction NOS Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/071868s032lbl.pdf Page: p.1

AEs

AE	Significance	Dose	Population
Diarrhea	grade 3, 66.7% Disc. AE	4.5 g/m2 2 times / day multiple, intravenous Highest studied dose Dose: 4.5 g/m2, 2 times / day Route: intravenous Route: multiple Dose: 4.5 g/m2, 2 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/6223674 Page: p.363, 366	unhealthy, 16-76 n = 6 Health Status: unhealthy Condition: Acute leukemia Age Group: 16-76 Sex: M+F Population Size: 6 Sources: https://pubmed.ncbi.nlm.nih.gov/6223674 Page: p.363, 366
Cerebellar disorder NOS	grade 4, 66.7% Disc. AE	4.5 g/m2 2 times / day multiple, intravenous Highest studied dose Dose: 4.5 g/m2, 2 times / day Route: intravenous Route: multiple Dose: 4.5 g/m2, 2 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/6223674 Page: p.363, 366	unhealthy, 16-76 n = 6 Health Status: unhealthy Condition: Acute leukemia Age Group: 16-76 Sex: M+F Population Size: 6 Sources: https://pubmed.ncbi.nlm.nih.gov/6223674 Page: p.363, 366
Cerebellar disorder NOS	grade 4, 33.3% Disc. AE	4.5 g/m2 2 times / day multiple, intravenous Highest studied dose Dose: 4.5 g/m2, 2 times / day Route: intravenous Route: multiple Dose: 4.5 g/m2, 2 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/7306918 Page: p.2578	unhealthy, 16-76 n = 6 Health Status: unhealthy Condition: Acute leukemia Age Group: 16-76 Sex: M+F Population Size: 6 Sources: https://pubmed.ncbi.nlm.nih.gov/7306918 Page: p.2578
Cerebellar disorder NOS	grade 5, 16.7% Disc. AE	4.5 g/m2 2 times / day multiple, intravenous Highest studied dose Dose: 4.5 g/m2, 2 times / day Route: intravenous Route: multiple Dose: 4.5 g/m2, 2 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/7306918 Page: p.2578	unhealthy, 16-76 n = 6 Health Status: unhealthy Condition: Acute leukemia Age Group: 16-76 Sex: M+F Population Size: 6 Sources: https://pubmed.ncbi.nlm.nih.gov/7306918 Page: p.2578
Abdominal pain	Disc. AE	100 mg/m2 1 times / day multiple, intravenous Recommended Dose: 100 mg/m2, 1 times / day Route: intravenous Route: multiple Dose: 100 mg/m2, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/071868s032lbl.pdf Page: p.1	unhealthy Health Status: unhealthy Condition: Acute non-lymphocytic leukemia Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/071868s032lbl.pdf Page: p.1
Anemia	Disc. AE	100 mg/m2 1 times / day multiple, intravenous Recommended Dose: 100 mg/m2, 1 times / day Route: intravenous Route: multiple Dose: 100 mg/m2, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/071868s032lbl.pdf Page: p.1	unhealthy Health Status: unhealthy Condition: Acute non-lymphocytic leukemia Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/071868s032lbl.pdf Page: p.1
Bone marrow depression	Disc. AE	100 mg/m2 1 times / day multiple, intravenous Recommended Dose: 100 mg/m2, 1 times / day Route: intravenous Route: multiple Dose: 100 mg/m2, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/071868s032lbl.pdf Page: p.1	unhealthy Health Status: unhealthy Condition: Acute non-lymphocytic leukemia Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/071868s032lbl.pdf Page: p.1
Diarrhea	Disc. AE	100 mg/m2 1 times / day multiple, intravenous Recommended Dose: 100 mg/m2, 1 times / day Route: intravenous Route: multiple Dose: 100 mg/m2, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/071868s032lbl.pdf Page: p.1	unhealthy Health Status: unhealthy Condition: Acute non-lymphocytic leukemia Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/071868s032lbl.pdf Page: p.1
Hepatic dysfunction NOS	Disc. AE	100 mg/m2 1 times / day multiple, intravenous Recommended Dose: 100 mg/m2, 1 times / day Route: intravenous Route: multiple Dose: 100 mg/m2, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/071868s032lbl.pdf Page: p.1	unhealthy Health Status: unhealthy Condition: Acute non-lymphocytic leukemia Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/071868s032lbl.pdf Page: p.1
Leukopenia	Disc. AE	100 mg/m2 1 times / day multiple, intravenous Recommended Dose: 100 mg/m2, 1 times / day Route: intravenous Route: multiple Dose: 100 mg/m2, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/071868s032lbl.pdf Page: p.1	unhealthy Health Status: unhealthy Condition: Acute non-lymphocytic leukemia Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/071868s032lbl.pdf Page: p.1
Nausea	Disc. AE	100 mg/m2 1 times / day multiple, intravenous Recommended Dose: 100 mg/m2, 1 times / day Route: intravenous Route: multiple Dose: 100 mg/m2, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/071868s032lbl.pdf Page: p.1	unhealthy Health Status: unhealthy Condition: Acute non-lymphocytic leukemia Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/071868s032lbl.pdf Page: p.1
Oral ulceration	Disc. AE	100 mg/m2 1 times / day multiple, intravenous Recommended Dose: 100 mg/m2, 1 times / day Route: intravenous Route: multiple Dose: 100 mg/m2, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/071868s032lbl.pdf Page: p.1	unhealthy Health Status: unhealthy Condition: Acute non-lymphocytic leukemia Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/071868s032lbl.pdf Page: p.1
Thrombocytopenia	Disc. AE	100 mg/m2 1 times / day multiple, intravenous Recommended Dose: 100 mg/m2, 1 times / day Route: intravenous Route: multiple Dose: 100 mg/m2, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/071868s032lbl.pdf Page: p.1	unhealthy Health Status: unhealthy Condition: Acute non-lymphocytic leukemia Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/071868s032lbl.pdf Page: p.1
Vomiting	Disc. AE	100 mg/m2 1 times / day multiple, intravenous Recommended Dose: 100 mg/m2, 1 times / day Route: intravenous Route: multiple Dose: 100 mg/m2, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/071868s032lbl.pdf Page: p.1	unhealthy Health Status: unhealthy Condition: Acute non-lymphocytic leukemia Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/071868s032lbl.pdf Page: p.1

Overview

CYP3A4	CYP2C9	CYP2D6	hERG
substrate 1737 inhibitor 1587

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer

Drug as perpetrator

Target	Modality	Activity	Metabolite	Clinical evidence
CYP3A4 1925	inhibitor 3277 Sources: https://pubmed.ncbi.nlm.nih.gov/15204103/ Page: 4.0	yes [IC50 6.6 uM]

Drug as victim

Target	Modality	Activity	Metabolite	Clinical evidence
CYP3A4 1737	substrate 3367 Sources: https://pubmed.ncbi.nlm.nih.gov/15204103/ Page: 4.0	yes

Sourcing

Vendor/Aggregator	ID	URL
ChEBI	CHEBI:28680	https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:28680
MolPort	MolPort-001-792-509	https://www.molport.com/shop/molecule-link/MolPort-001-792-509
Selleck Chemicals	Cytarabine(Cytosar-U)	http://www.selleckchem.com/products/Cytarabine(Cytosar-U).html
ZINC	ZINC000003795098	http://zinc15.docking.org/substances/ZINC000003795098
eMolecules	1012736	https://www.emolecules.com/cgi-bin/more?vid=1012736

PubMed

Title	Date	PubMed
Lenograstim and filgrastim effects on neutrophil motility in patients undergoing chemotherapy: evaluation by computer-assisted image analysis.	2001 Apr	11279646
Primary high-grade mucosa-associated lymphoid tissue-type lymphoma of the cervix presenting as a common endocervical polyp.	2001 Apr	11260632
2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine: a novel anticancer nucleoside analog that causes both DNA strand breaks and G(2) arrest.	2001 Apr	11259616
The neuron-glia signal beta-neuregulin promotes Schwann cell motility via the MAPK pathway.	2001 Apr 1	11284018
Value of high-dose cytarabine during interval therapy of a Berlin-Frankfurt-Munster-based protocol in increased-risk children with acute lymphoblastic leukemia and lymphoblastic lymphoma: results of the European Organization for Research and Treatment of Cancer 58881 randomized phase III trial.	2001 Apr 1	11283125
In vitro cytotoxic effects of a tyrosine kinase inhibitor STI571 in combination with commonly used antileukemic agents.	2001 Apr 1	11264164
Respiratory chain-generated oxidative stress following treatment of leukemic blasts with DNA-damaging agents.	2001 Apr 1	11262191
The combination of chemotherapy and systemic immunotherapy with soluble B7-immunoglobulin G leads to cure of murine leukemia and lymphoma and demonstration of tumor-specific memory responses.	2001 Apr 15	11290606
Involvement of oxygen radicals in cytarabine-induced apoptosis in human polymorphonuclear cells.	2001 Apr 15	11286995
Parotid mucoepidermoid carcinoma following chemotherapy for childhood acute lymphoblastic leukemia.	2001 Apr-May	11293291
Prognostic value of day 14 blast percentage and the absolute blast index in bone marrow of children with acute lymphoblastic leukemia.	2001 Apr-May	11293286
[Philadelphia chromosome-positive acute lymphoblastic leukemia with monosomy 7 successfully treated with intermediate- and high-dose ara-C].	2001 Feb	11280917
Chemotherapy for acute myelogenous leukemia in the elderly with cytarabine, mitoxantrone, and granulocyte-macrophage colony-stimulating factor.	2001 Feb	11232951
Temporary response of localized intracranial mast cell sarcoma to combination chemotherapy.	2001 Feb	11216707
Bone marrow involvement by nasal NK cell lymphoma at diagnosis is uncommon.	2001 Feb	11211616
[Is it useful to perform a (67)gallium scintigraphy in the follow-up of patients with gastric lymphoma?].	2001 Feb	11181327
Mutations in ras proto-oncogenes are associated with lower mdr1 gene expression in adult acute myeloid leukaemia.	2001 Feb	11167822
Results of intensive chemotherapy followed by hematopoietic stem-cell rescue in 22 patients with refractory or recurrent primary CNS lymphoma or intraocular lymphoma.	2001 Feb 1	11157026
Transfusion of peripheral blood stem cells from donor homozygous for a shared HLA-haplotype: avoiding fatal transfusion-associated graft-versus-host disease while preserving anti-leukemic effect.	2001 Feb 15	11233917
Topoisomerase II inhibitor induced leukemia in a patient with AIDS.	2001 Feb 16	11273227
Survival in patients with intermediate or high grade non-Hodgkin's lymphoma: meta-analysis of randomized studies comparing third generation regimens with CHOP.	2001 Feb 2	11161392
Allogeneic bone marrow transplantation in children failing prior autologous bone marrow transplantation.	2001 Jan	11281384
The biology and treatment of chronic myelogenous leukemia.	2001 Jan	11271979
[Outcome of acute myelogenous leukemia in 41 patients treated with idarubicin: the prognosis of t(8;21) cases].	2001 Jan	11235129
Aseptic meningitis in a child after systemic treatment with high dose cytarabine.	2001 Jan	11176579
Patients with de novo acute myeloid leukaemia and complex karyotype aberrations show a poor prognosis despite intensive treatment: a study of 90 patients.	2001 Jan	11167792
Intrathecal treatment of neoplastic meningitis due to breast cancer with a slow-release formulation of cytarabine.	2001 Jan	11161370
PBPC mobilization with chemotherapy and G-CSF in patients with chronic myeloid leukemia: quantification of bcr/abl-positive cells by interphase fluorescence in situ hybridization and competitive PCR.	2001 Jan	11161255
Acute progranulocytic leukemia.	2001 Jan	11148679
De novo acute myeloid leukemia in the elderly; a consistent fraction of long-term survivors by standard-dose chemotherapy.	2001 Jan	11137558
Chemotherapy and marrow transplantation for congenital leukaemia.	2001 Jan	11124925
Simultaneous treatment with 1-beta-D-arabinofuranosylcytosine and daunorubicin induces cross-resistance to both drugs due to a combination-specific mechanism in HL60 cells.	2001 Jan 1	11196156
Primary central nervous system lymphoma 1991-1997: outcome and late adverse effects after combined modality treatment.	2001 Jan 1	11148569
Reduced cellular transport and activation of fluoropyrimidine nucleosides and resistance in human lymphocytic cell lines selected for arabinosylcytosine resistance.	2001 Jan 1	11137707
Porcine Choroid plexus epithelial cells in culture: regulation of barrier properties and transport processes.	2001 Jan 1	11135456
Targeting and anti-tumor efficacy of liposomal 5'-O-dipalmitoylphosphatidyl 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine in mice lung bearing B16BL6 melanoma.	2001 Jan 10	11121862
JP-8 jet fuel-induced DNA damage in H4IIE rat hepatoma cells.	2001 Jan 25	11152973
Serum LDH, a prognostic factor in elderly patients with acute myelogenous leukaemia.	2001 Jan 5	11139330
The CAG regimen (low-dose cytarabine, aclarubicin hydrochloride and granulocyte colony-stimulating factor) for the treatment of elderly acute myelomonocytic leukaemia: a case study.	2001 Jan-Feb	11277347
Toxic epidermal necrolysis after the use of high-dose cytosine arabinoside.	2001 Jan-Feb	11207969
Therapy of acute myeloid leukemia.	2001 Jan-Feb	11176038
Outcome of relapsed or refractory childhood B-cell acute lymphoblastic leukaemia and B-cell non-Hodgkin's lymphoma treated with the UKCCSG 9003/9002 protocols.	2001 Mar	11298592
Neutrophilic eccrine hidradenitis in two neutropaenic patients.	2001 Mar	11298106
[All-trans retinoic acid combined with low-dose cytosine arabinoside treatment for acute myelogenous leukemia with trilineage myelodysplasia--a case report].	2001 Mar	11265415
Cytogenetic subgroups in acute myeloid leukemia differ in proliferative activity and response to GM-CSF.	2001 Mar	11237060
Combination chemotherapy utilizing continuous infusion of intermediate-dose cytarabine for refractory or recurrent acute myeloid leukemia.	2001 Mar	11226516
Isodicentric 7p, idic(7)(q11.2), in acute myeloid leukemia associated with older age and favorable response to induction chemotherapy: a new clinical entity?	2001 Mar	11170283
Severe hepatic injury associated with lipid formulations of amphotericin B.	2001 Mar 1	11229863
Total body irradiation before allogeneic bone marrow transplantation: is more dose better?	2001 Mar 15	11240249
Circumvention of ara-C resistance by aphidicolin in blast cells from patients with AML.	2001 Mar 2	11237390

Patents

Sample Use Guides

In Vivo Use Guide

Induction therapy: DepoCyt (cytarabine liposome injection), 50 mg, administered intrathecally (intraventricular or lumbar puncture) every 14 days for 2 doses (weeks 1 and 3). Consolidation therapy: DepoCyt, 50 mg, administered intrathecally (intraventricular or lumbar puncture) every 14 days for 3 doses (weeks 5, 7 and 9) followed by 1 additional dose at week 13. Maintenance: DepoCyt, 50 mg, administered intrathecally (intraventricular or lumbar puncture) every 28 days for 4 doses (weeks 17, 21, 25 and 29).

Route of Administration: Intratracheal

In Vitro Use Guide

Human umbilical vein endothelial cells (HUVECs) and human osteosarcoma cell line (Cal72) were incubated with various concentrations of Cytarabine (Ara-C) (0.01–20 μM) for 3 days

Name

Type

Language

CYTARABINE HYDROCHLORIDE

Official Name

English

2(1H)-PYRIMIDINONE, 4-AMINO-1-.BETA.-D-ARABINOFURANOSYL-, MONOHYDROCHLORIDE

Common Name

English

U-19920A

Code

English

Cytarabine hydrochloride [WHO-DD]

Common Name

English

CYTARABINE HYDROCHLORIDE [USAN]

Common Name

English

1-.BETA.-D-ARABINOFURANOSYLCYTOSINE MONOHYDROCHLORIDE

Common Name

English

CYTARABINE HCL

Common Name

English

CYTOSINE ARABINOSIDE HYDROCHLORIDE

Common Name

English

NSC-63878

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C1557