Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C25H23N5O6S |
| Molecular Weight | 521.545 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)[C@H](NC(=O)C3=CN=C4C=CC=NC4=C3O)C5=CC=CC=C5)C(O)=O
InChI
InChIKey=XMQVYNAURODYCQ-SLFBBCNNSA-N
InChI=1S/C25H23N5O6S/c1-25(2)19(24(35)36)30-22(34)17(23(30)37-25)29-21(33)15(12-7-4-3-5-8-12)28-20(32)13-11-27-14-9-6-10-26-16(14)18(13)31/h3-11,15,17,19,23H,1-2H3,(H,27,31)(H,28,32)(H,29,33)(H,35,36)/t15-,17-,19+,23-/m1/s1
Apalcillin is a naphthydridine derivative of ampicillin. Apalcillin has a broad spectrum of antibacterial activity that is very similar to that of piperacillin, except that apalcillin is significantly more active against Pseudomonas aeruginosa and Acinetobacter spp. Against Acinetobacter spp., apalcillin is uniquely active, compared to the other penicillins and comparison drugs. Strains producing high amounts of β-lactamases do become resistant to apalcillin. PAH (p-aminohippurate) clearance was significantly decreased during apalcillin infusion. Apalcillin appeared to compete with PAH for proximal tubular secretion but induced no further renal dysfunction.
Approval Year
| Name | Type | Language | ||
|---|---|---|---|---|
|
Official Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English |
| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
|
NCI_THESAURUS |
C1500
Created by
admin on Fri Dec 15 16:32:50 GMT 2023 , Edited by admin on Fri Dec 15 16:32:50 GMT 2023
|
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
m1980
Created by
admin on Fri Dec 15 16:32:50 GMT 2023 , Edited by admin on Fri Dec 15 16:32:50 GMT 2023
|
PRIMARY | Merck Index | ||
|
C76217
Created by
admin on Fri Dec 15 16:32:50 GMT 2023 , Edited by admin on Fri Dec 15 16:32:50 GMT 2023
|
PRIMARY | |||
|
DTXSID60101650
Created by
admin on Fri Dec 15 16:32:50 GMT 2023 , Edited by admin on Fri Dec 15 16:32:50 GMT 2023
|
PRIMARY | |||
|
51691
Created by
admin on Fri Dec 15 16:32:50 GMT 2023 , Edited by admin on Fri Dec 15 16:32:50 GMT 2023
|
PRIMARY | |||
|
SUB05535MIG
Created by
admin on Fri Dec 15 16:32:50 GMT 2023 , Edited by admin on Fri Dec 15 16:32:50 GMT 2023
|
PRIMARY | |||
|
CHEMBL3306902
Created by
admin on Fri Dec 15 16:32:50 GMT 2023 , Edited by admin on Fri Dec 15 16:32:50 GMT 2023
|
PRIMARY | |||
|
227
Created by
admin on Fri Dec 15 16:32:50 GMT 2023 , Edited by admin on Fri Dec 15 16:32:50 GMT 2023
|
PRIMARY | |||
|
4422
Created by
admin on Fri Dec 15 16:32:50 GMT 2023 , Edited by admin on Fri Dec 15 16:32:50 GMT 2023
|
PRIMARY | |||
|
3373RT9U7A
Created by
admin on Fri Dec 15 16:32:50 GMT 2023 , Edited by admin on Fri Dec 15 16:32:50 GMT 2023
|
PRIMARY | |||
|
C012122
Created by
admin on Fri Dec 15 16:32:50 GMT 2023 , Edited by admin on Fri Dec 15 16:32:50 GMT 2023
|
PRIMARY | |||
|
100000086956
Created by
admin on Fri Dec 15 16:32:50 GMT 2023 , Edited by admin on Fri Dec 15 16:32:50 GMT 2023
|
PRIMARY | |||
|
6602341
Created by
admin on Fri Dec 15 16:32:50 GMT 2023 , Edited by admin on Fri Dec 15 16:32:50 GMT 2023
|
PRIMARY | |||
|
63469-19-2
Created by
admin on Fri Dec 15 16:32:50 GMT 2023 , Edited by admin on Fri Dec 15 16:32:50 GMT 2023
|
PRIMARY |
ACTIVE MOIETY
SALT/SOLVATE (PARENT)
