Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C95H110N8O44 |
| Molecular Weight | 2067.9171 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 37 / 37 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@]12NC(=O)[C@@H]3NC(=O)[C@H]4NC(=O)[C@H](NC(=O)[C@H](N)C5=CC(OC6=CC4=CC(O)=C6C)=C(O)C=C5)[C@H](O)C7=CC=C(OC8=C(O[C@@H]9O[C@H](CO[C@@H]%10O[C@@H](C)[C@H](O)[C@@H](O)[C@H]%10O)[C@@H](O)[C@H](O)[C@H]9O[C@H]%11O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]%11O[C@@H]%12OC[C@@H](O)[C@@H](O)[C@@H]%12O)C(OC%13=CC=C(C=C%13)[C@@H](O[C@H]%14C[C@@H](N)[C@@H](O)[C@H](C)O%14)[C@H](NC1=O)C(=O)N[C@H](C(=O)OC)C%15=CC(O)=CC(O[C@@H]%16O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]%16O)=C%15C%17=C(O)C=CC2=C%17)=CC3=C8)C=C7
InChI
InChIKey=VUOPFFVAZTUEGW-SRXUPNLNSA-N
InChI=1S/C95H110N8O44/c1-30-47(109)18-37-20-49(30)139-50-19-35(9-16-46(50)108)59(97)84(125)102-64-68(113)33-5-11-40(12-6-33)137-52-21-38-22-53(81(52)145-95-83(76(121)72(117)56(143-95)29-134-91-78(123)73(118)67(112)32(3)136-91)147-94-82(75(120)71(116)55(27-105)142-94)146-92-77(122)69(114)48(110)28-133-92)138-41-13-7-34(8-14-41)80(144-57-25-44(96)66(111)31(2)135-57)65-89(130)101-63(90(131)132-4)43-23-39(106)24-51(140-93-79(124)74(119)70(115)54(26-104)141-93)58(43)42-17-36(10-15-45(42)107)60(85(126)103-65)98-87(128)62(38)99-86(127)61(37)100-88(64)129/h5-24,31-32,44,48,54-57,59-80,82-83,91-95,104-124H,25-29,96-97H2,1-4H3,(H,98,128)(H,99,127)(H,100,129)(H,101,130)(H,102,125)(H,103,126)/t31-,32-,44+,48+,54+,55+,56+,57-,59+,60+,61-,62+,63-,64+,65-,66-,67-,68+,69+,70+,71+,72+,73+,74-,75-,76-,77-,78+,79-,80+,82-,83+,91+,92-,93+,94+,95-/m0/s1
Ristocetin A is an antibiotic, derived from Nocardia lurida and exerts bactericidal effect against a range of Gram-positive cocci, Gramnegative diplococci, and Myco. tuberculosis. Ristocetin A and B were applied to treat staphylococcal infections but no longer used clinically because it caused thrombocytopenia and platelet agglutination. The Von Willebrand Ristocetin Cofactor [vWF:RCo] assay measures the ability of a patient’s plasma to agglutinate platelets in the presence of the antibiotic Ristocetin. The rate of Ristocetin induced agglutination is related to the concentration and functional activity of the plasma von Willebrand factor. Ristocetin is thought to bind to VWF at Glu1239-Pro-Gly Gly1242.
Originator
Approval Year
Sample Use Guides
25 mg. per kg. body weight
Route of Administration:
Intravenous
In studies on the natural bacterial resistance to Ristocetin was revealed that none of 400 clinically-isolated cultures of streptococci, staphylococci or pneumococci were resistant. Serial transfer did not readily result in resistance, although two strains of staphylococci were made 100-fold resistant to Ristocetin A. MICs of Ristocetin for Staphylococcus aureus and Streptococcus pyogenes are 4-8 and 0.5-1 ug/ml, respectively.
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11021-66-2
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32P08CBB99
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DTXSID801317931
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m9632
Created by
admin on Sat Dec 16 08:39:27 GMT 2023 , Edited by admin on Sat Dec 16 08:39:27 GMT 2023
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76970502
Created by
admin on Sat Dec 16 08:39:27 GMT 2023 , Edited by admin on Sat Dec 16 08:39:27 GMT 2023
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ACTIVE MOIETY
