Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C19H18F6N4O3 |
| Molecular Weight | 464.3616 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC(=O)C1=C2CN(CCN2C(=N1)C(F)(F)F)C(=O)C[C@H](N)CC3=C(F)C=C(F)C(F)=C3
InChI
InChIKey=WIIAMRXFUJLYEF-SNVBAGLBSA-N
InChI=1S/C19H18F6N4O3/c1-32-17(31)16-14-8-28(2-3-29(14)18(27-16)19(23,24)25)15(30)6-10(26)4-9-5-12(21)13(22)7-11(9)20/h5,7,10H,2-4,6,8,26H2,1H3/t10-/m1/s1
SP-2086 H3PO4 (Retagliptin Phosphate), tetrahydro-imidazo[1,5-a] pyrazine
derivative, is a competitive DPP-4 inhibitor innovated in China under development by Jiangsu Hengrui Medicine for the treatment of Type 2 diabetes. In completed phase II trials, retagliptin monotherapy or in combination with metformin significantly decreased the HbA1c level in type 2 diabetic patients. Two phase III trials for retagliptin monotherapy aCnd in combination with metformin, respectively, were ongoing in China. Jiangsu Hengrui Medicine withdrew its application from the Chinese
FDA in April 2016 but is expected to refile the application.
Originator
Approval Year
Sample Use Guides
The dosage of phosphate retagliptin tablet is recommended at 100 mg/d for patients with normal renal function and those with mild renal dysfunction,at 50 mg/d for patients with moderate renal dysfunction,and at 25 mg/d for patients with severe renal dysfunction.
Route of Administration:
Oral
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Code | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
328C4R3P9L
Created by
admin on Fri Dec 15 16:07:32 GMT 2023 , Edited by admin on Fri Dec 15 16:07:32 GMT 2023
|
PRIMARY | |||
|
DB14898
Created by
admin on Fri Dec 15 16:07:32 GMT 2023 , Edited by admin on Fri Dec 15 16:07:32 GMT 2023
|
PRIMARY | |||
|
44193830
Created by
admin on Fri Dec 15 16:07:32 GMT 2023 , Edited by admin on Fri Dec 15 16:07:32 GMT 2023
|
PRIMARY | |||
|
1174122-54-3
Created by
admin on Fri Dec 15 16:07:32 GMT 2023 , Edited by admin on Fri Dec 15 16:07:32 GMT 2023
|
PRIMARY |
ACTIVE MOIETY
SALT/SOLVATE (PARENT)
