DIMOXAMINE HYDROCHLORIDE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C13H21NO2.ClH
Molecular Weight	259.772
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CC[C@@H](N)CC1=C(OC)C=C(C)C(OC)=C1

InChI

InChIKey=HQMDHDKBZGKPGS-RFVHGSKJSA-N

InChI=1S/C13H21NO2.ClH/c1-5-11(14)7-10-8-12(15-3)9(2)6-13(10)16-4;/h6,8,11H,5,7,14H2,1-4H3;1H/t11-;/m1./s1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/402669 | https://www.ncbi.nlm.nih.gov/pubmed/263545 | https://www.ncbi.nlm.nih.gov/pubmed/6776559 | https://www.ncbi.nlm.nih.gov/pubmed/959651

Dimoxamine is a memory adjuvant. Dimoxamine hydrochloride has been reported to facilitate the performance of naive rats in a massed trial shuttle box task. At doses that facilitated shuttle box responding, dimoxamine had no effect on unacclimated motor activity of rats nor on the rate of continuous avoidance responding by rats. Dimoxamine has a psychopharmacological profile that is different from other phenylalkylamines such as S-amphetamine and R-DOM. Dimoxamine may prove beneficial in the treatment of individuals having low or deteriorated levels of certain types of associative and psychomotor abilities. Dimoxamine substituted completely for LSD. Dimoxamine can be classified as a partial agonist of 5-HT receptors in sheep umbilical arteries.

Approval Year

PubMed

Title	Date	PubMed
Cardiovascular and gross behavioral effects of amphetamine, 2-amino-1-(2,5-dimethoxy-4-methylphenyl) propane (DOM) and 2-amino-1-(2,5-dimethoxy-4-methylphenyl) butane (BL-3912A) in the conscious dog.	1974 Jun	4859236
Comparison of the effects of R-(-)-2-amino-1-(2,5-dimethoxy-4-methylphenyl) propane (DOM), r-(-)-2-amino-1-(2,5-dimethoxy-4-methylphenyl) butane (BL-3912A) and 5-hydroxytryptamine on non-innervated vascular smooth muscle.	1976 Jul	959651
Behavioral comparisons of R-2-amino-1-(2,5-dimethoxy-4-methylphenyl) butane (BL-3912A) with R-DOM and S-amphetamine.	1977 Jan 31	402669
Further studies on BL-3912A: effects on avoidance behavior of rats with low baselines and on reaction thresholds to electric footshock.	1977 Jun	263545
Effects of the phenethylamine derivatives, BL-3912, fenfluramine, and Sch-12679, in rats trained with LSD as a discriminative stimulus.	1980	6776559
MDMA-like stimulus effects of alpha-ethyltryptamine and the alpha-ethyl homolog of DOM.	1993 Oct	7903460

Sample Use Guides

In Vivo Use Guide

5, 10 and 20 mg/kg

Route of Administration: Intraperitoneal

Name

Type

Language

DIMOXAMINE HYDROCHLORIDE

Official Name

English

BL-3912A

Code

English

(R)-α-Ethyl-2,5-dimethoxy-4-methylphenethylamine hydrochloride

Systematic Name

English

NSC-292248

Code

English

DIMOXAMINE HYDROCHLORIDE, (R)-

Common Name

English

BENZENEETHANAMINE, .ALPHA.-ETHYL-2,5-DIMETHOXY-4-METHYL-, HYDROCHLORIDE (1:1), (.ALPHA.R)-

Systematic Name

English

BENZENEETHANAMINE, .ALPHA.-ETHYL-2,5-DIMETHOXY-4-METHYL-, HYDROCHLORIDE, (R)-

Systematic Name

English

DIMOXAMINE HYDROCHLORIDE [USAN]

Common Name

English

Code System Code Type Description

ChEMBL

CHEMBL433696