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Details

Stereochemistry ACHIRAL
Molecular Formula C16H19N3S.2CH4O3S
Molecular Weight 477.618
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of HYDROMETHYLTHIONINE MESYLATE

SMILES

CS(O)(=O)=O.CS(O)(=O)=O.CN(C)C1=CC2=C(NC3=C(S2)C=C(C=C3)N(C)C)C=C1

InChI

InChIKey=SPCMQFLNOVTUBM-UHFFFAOYSA-N
InChI=1S/C16H19N3S.2CH4O3S/c1-18(2)11-5-7-13-15(9-11)20-16-10-12(19(3)4)6-8-14(16)17-13;2*1-5(2,3)4/h5-10,17H,1-4H3;2*1H3,(H,2,3,4)

HIDE SMILES / InChI

Description

L-MTX is a second-generation tau protein aggregation inhibitor. It acts by reducing levels of aggregated or misfolded tau proteins, which are associated with the progressive neurodegeneration. It is currently under development for the treatment of Alzheimer’s disease.

Originator

Approval Year

Unknown
139594
Targets

Targets

Primary TargetPharmacologyConditionPotency
Inhibitor
8297
 0.12 µM [Ki]
PubMed

PubMed

TitleDatePubMed
Tau-aggregation inhibitor therapy for Alzheimer's disease.
2014 Apr 15
Cellular Models of Aggregation-dependent Template-directed Proteolysis to Characterize Tau Aggregation Inhibitors for Treatment of Alzheimer Disease.
2015 Apr 24
Efficacy and safety of tau-aggregation inhibitor therapy in patients with mild or moderate Alzheimer's disease: a randomised, controlled, double-blind, parallel-arm, phase 3 trial.
2016 Dec 10
Patents

Patents

20030044316
3
JP2007010382A
3

Sample Use Guides

In Vivo Use Guide
L-MTX is given as a monotherapy at doses of 8 mg/day (taken as 4 mg twice daily) and of 16 mg/day (taken as 8 mg twice daily).
Route of Administration: Oral
Name Type Language
HYDROMETHYLTHIONINE MESYLATE
USAN  
Official Name English
TRX-0237
Code English
LMTM
Common Name English
LEUCOMETHYLENE BLUE BISMESYLATE
Common Name English
LEUCO-METHYLTHIONINIUM DIMESYLATE
Common Name English
LMTX
Code English
LEUCOMETHYLENE BLUE DIMESYLATE
Common Name English
TRX0237
Code English
HYDROMETHYLTHIONINE MESYLATE [USAN]
Common Name English
N,N,N',N'-TETRAMETHYL-10H-PHENOTHIAZINE-3,7-DIAMINIUM BIS(METHANESULFONATE)
Systematic Name English
LEUCO-METHYLTHIONINIUM BIS(HYDROMETHANESULFONATE)
Common Name English
10H-PHENOTHIAZINE-3,7-DIAMINE, N3,N3,N7,N7-TETRAMETHYL-, METHANESULFONATE (1:2)
Systematic Name English
Classification Tree Code System Code
FDA ORPHAN DRUG 661118
Created by admin on Sat Dec 16 09:12:18 GMT 2023 , Edited by admin on Sat Dec 16 09:12:18 GMT 2023
Code System Code Type Description
USAN
CD-178
Created by admin on Sat Dec 16 09:12:18 GMT 2023 , Edited by admin on Sat Dec 16 09:12:18 GMT 2023
PRIMARY
PUBCHEM
60150609
Created by admin on Sat Dec 16 09:12:18 GMT 2023 , Edited by admin on Sat Dec 16 09:12:18 GMT 2023
PRIMARY
FDA UNII
3248SEF29D
Created by admin on Sat Dec 16 09:12:18 GMT 2023 , Edited by admin on Sat Dec 16 09:12:18 GMT 2023
PRIMARY
EVMPD
SUB189816
Created by admin on Sat Dec 16 09:12:18 GMT 2023 , Edited by admin on Sat Dec 16 09:12:18 GMT 2023
PRIMARY
NCI_THESAURUS
C166629
Created by admin on Sat Dec 16 09:12:18 GMT 2023 , Edited by admin on Sat Dec 16 09:12:18 GMT 2023
PRIMARY
CAS
1236208-20-0
Created by admin on Sat Dec 16 09:12:17 GMT 2023 , Edited by admin on Sat Dec 16 09:12:17 GMT 2023
PRIMARY
SMS_ID
100000175425
Created by admin on Sat Dec 16 09:12:18 GMT 2023 , Edited by admin on Sat Dec 16 09:12:18 GMT 2023
PRIMARY
NIH
NCATS
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