Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C19H21BrN2O3S |
| Molecular Weight | 437.351 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
BrC1=CC(NC(=O)C2=CC=CC(=C2)S(=O)(=O)N3CCCCCC3)=CC=C1
InChI
InChIKey=IYAYHZZWYNXHEQ-UHFFFAOYSA-N
InChI=1S/C19H21BrN2O3S/c20-16-8-6-9-17(14-16)21-19(23)15-7-5-10-18(13-15)26(24,25)22-11-3-1-2-4-12-22/h5-10,13-14H,1-4,11-12H2,(H,21,23)
DescriptionCurator's Comment: Description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/23200855 | https://www.ncbi.nlm.nih.gov/pubmed/27372638 | https://www.ncbi.nlm.nih.gov/pubmed/26089639
Curator's Comment: Description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/23200855 | https://www.ncbi.nlm.nih.gov/pubmed/27372638 | https://www.ncbi.nlm.nih.gov/pubmed/26089639
AK-7 is a brain penetrant selective SIRT2 inhibitor. AK-7 exerts neuroprotective properties in vitro and in vivo models of neurodegenerative
diseases (Huntington’s, Parkinson’s and Alzheimer’s disease).
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| A brain-permeable small molecule reduces neuronal cholesterol by inhibiting activity of sirtuin 2 deacetylase. | 2011 Jun 17 |
|
| Aging-related rotenone-induced neurochemical and behavioral deficits: role of SIRT2 and redox imbalance, and neuroprotection by AK-7. | 2015 |
|
| Sirtuin 2 Inhibition Improves Cognitive Performance and Acts on Amyloid-β Protein Precursor Processing in Two Alzheimer's Disease Mouse Models. | 2016 Jun 30 |
|
| Aging-related 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurochemial and behavioral deficits and redox dysfunction: improvement by AK-7. | 2016 Sep |
Patents
Sample Use Guides
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Systematic Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
420831-40-9
Created by
admin on Sat Dec 16 09:34:33 GMT 2023 , Edited by admin on Sat Dec 16 09:34:33 GMT 2023
|
PRIMARY | |||
|
1328033
Created by
admin on Sat Dec 16 09:34:33 GMT 2023 , Edited by admin on Sat Dec 16 09:34:33 GMT 2023
|
PRIMARY | |||
|
DTXSID30194926
Created by
admin on Sat Dec 16 09:34:33 GMT 2023 , Edited by admin on Sat Dec 16 09:34:33 GMT 2023
|
PRIMARY | |||
|
308B6B695N
Created by
admin on Sat Dec 16 09:34:33 GMT 2023 , Edited by admin on Sat Dec 16 09:34:33 GMT 2023
|
PRIMARY |
ACTIVE MOIETY
