OXOMEMAZINE

Details

Stereochemistry	RACEMIC
Molecular Formula	C18H22N2O2S
Molecular Weight	330.444
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(CN(C)C)CN1C2=CC=CC=C2S(=O)(=O)C3=CC=CC=C13

InChI

InChIKey=QTQPVLDZQVPLGV-UHFFFAOYSA-N

InChI=1S/C18H22N2O2S/c1-14(12-19(2)3)13-20-15-8-4-6-10-17(15)23(21,22)18-11-7-5-9-16(18)20/h4-11,14H,12-13H2,1-3H3

HIDE SMILES / InChI

Description
Sources: https://www.drugs.com/international/oxomemazine.html | https://www.moncoinsante.co.uk/oxomemazine-toux-seche-sirop-gobelet-doseur-150-ml-biogaran-generique-du-toplexil.html#description | https://www.ncbi.nlm.nih.gov/pubmed/10319156 | https://www.ncbi.nlm.nih.gov/pubmed/12611200

Oxomemazine is a histamine H₁-receptor antagonist. Additionally, oxomemazine could be classified as a ligand for M1 receptors. It is used in the symptomatic treatment of non-productive coughs that occur specifically at night.

Approval Year

PubMed

Title	Date	PubMed
Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.	2010 Dec	21818443

Sample Use Guides

In Vivo Use Guide

Oxomemazine 0.33 mg/ml syrup. Suitable for adults and children over 40 kg (from the age of 12 years old). 10 ml 4 times per day. For children: The daily dose according to a child’s weight (1ml of syrup per kg per day): · Child between 13-20 kg (between 2-6 years old): 5ml 2-3 times per day. · Child between 20-30 kg (between 6-10 years old): 10 ml 2-3 times per day. · Child between 30-40 kg (between 10-12 years old): 10 ml 3-4 times a day. Repeat if necessary minimum every 4 hours. Due to the sedative effect of oxomemazine it is advisable to take this medication in the evening.

Route of Administration: Oral

Name

Type

Language

OXOMEMAZINE

Official Name

English

EXE-TOP

Brand Name

English

oxomemazine [INN]

Common Name

English

OXOMEMAZINE [MART.]

Common Name

English

DOXERGAN

Brand Name

English

IMAKOL

Brand Name

English

10-(3-(DIMETHYLAMINO)-2-METHYLPROPYL)PHENOTHIAZINE 5,5-DIOXIDE

Systematic Name

English

OPLEX

Brand Name

English

DYSEDON

Brand Name

English

Oxomemazine [WHO-DD]

Common Name

English

PHENOTHIAZINE, 10-(3-(DIMETHYLAMINO)-2-METHYLPROPYL)-, 5,5-DIOXIDE

Systematic Name

English

OXOMEMAZINE [MI]

Common Name

English

6847-RP

Code

English

6487-RP

Code

English

TRIMEPRAZINE 5,5-DIOXIDE

Common Name

English

RP-6847

Code

English

RP 6847

Code

English

10H-PHENOTHIAZINE-10-PROPANAMINE, N,N,.BETA.-TRIMETHYL-, 5,5-DIOXIDE

Systematic Name

English

(±)-OXOMEMAZINE

Common Name

English

Classification Tree Code System Code

WHO-ATC

R06AD08