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Details

Stereochemistry RACEMIC
Molecular Formula C18H22N2O2S
Molecular Weight 330.444
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of OXOMEMAZINE

SMILES

CC(CN(C)C)CN1C2=CC=CC=C2S(=O)(=O)C3=CC=CC=C13

InChI

InChIKey=QTQPVLDZQVPLGV-UHFFFAOYSA-N
InChI=1S/C18H22N2O2S/c1-14(12-19(2)3)13-20-15-8-4-6-10-17(15)23(21,22)18-11-7-5-9-16(18)20/h4-11,14H,12-13H2,1-3H3

HIDE SMILES / InChI

Description

Oxomemazine is a histamine H₁-receptor antagonist. Additionally, oxomemazine could be classified as a ligand for M1 receptors. It is used in the symptomatic treatment of non-productive coughs that occur specifically at night.

Approval Year

Unknown
139594
PubMed

PubMed

TitleDatePubMed
Preliminary studies on phenothiazine-mediated reversal of multidrug resistance in mouse lymphoma and COLO 320 cells.
2005 Nov-Dec
Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.
2010 Dec

Sample Use Guides

In Vivo Use Guide
Oxomemazine 0.33 mg/ml syrup. Suitable for adults and children over 40 kg (from the age of 12 years old). 10 ml 4 times per day. For children: The daily dose according to a child’s weight (1ml of syrup per kg per day): · Child between 13-20 kg (between 2-6 years old): 5ml 2-3 times per day. · Child between 20-30 kg (between 6-10 years old): 10 ml 2-3 times per day. · Child between 30-40 kg (between 10-12 years old): 10 ml 3-4 times a day. Repeat if necessary minimum every 4 hours. Due to the sedative effect of oxomemazine it is advisable to take this medication in the evening.
Route of Administration: Oral
Name Type Language
OXOMEMAZINE
INN   MART.   MI   WHO-DD  
INN  
Official Name English
EXE-TOP
Brand Name English
oxomemazine [INN]
Common Name English
OXOMEMAZINE [MART.]
Common Name English
DOXERGAN
Brand Name English
IMAKOL
Brand Name English
10-(3-(DIMETHYLAMINO)-2-METHYLPROPYL)PHENOTHIAZINE 5,5-DIOXIDE
Systematic Name English
OPLEX
Brand Name English
DYSEDON
Brand Name English
Oxomemazine [WHO-DD]
Common Name English
PHENOTHIAZINE, 10-(3-(DIMETHYLAMINO)-2-METHYLPROPYL)-, 5,5-DIOXIDE
Systematic Name English
OXOMEMAZINE [MI]
Common Name English
6847-RP
Code English
6487-RP
Code English
TRIMEPRAZINE 5,5-DIOXIDE
Common Name English
RP-6847
Code English
RP 6847
Code English
10H-PHENOTHIAZINE-10-PROPANAMINE, N,N,.BETA.-TRIMETHYL-, 5,5-DIOXIDE
Systematic Name English
(±)-OXOMEMAZINE
Common Name English
Classification Tree Code System Code
WHO-ATC R06AD08
Created by admin on Sat Dec 16 16:45:36 GMT 2023 , Edited by admin on Sat Dec 16 16:45:36 GMT 2023
NCI_THESAURUS C29704
Created by admin on Sat Dec 16 16:45:36 GMT 2023 , Edited by admin on Sat Dec 16 16:45:36 GMT 2023
WHO-VATC QR06AD08
Created by admin on Sat Dec 16 16:45:36 GMT 2023 , Edited by admin on Sat Dec 16 16:45:36 GMT 2023
Code System Code Type Description
INN
1412
Created by admin on Sat Dec 16 16:45:36 GMT 2023 , Edited by admin on Sat Dec 16 16:45:36 GMT 2023
PRIMARY
DRUG BANK
DB13820
Created by admin on Sat Dec 16 16:45:36 GMT 2023 , Edited by admin on Sat Dec 16 16:45:36 GMT 2023
PRIMARY
NCI_THESAURUS
C73008
Created by admin on Sat Dec 16 16:45:36 GMT 2023 , Edited by admin on Sat Dec 16 16:45:36 GMT 2023
PRIMARY
ECHA (EC/EINECS)
222-996-8
Created by admin on Sat Dec 16 16:45:36 GMT 2023 , Edited by admin on Sat Dec 16 16:45:36 GMT 2023
PRIMARY
FDA UNII
305MB38V1C
Created by admin on Sat Dec 16 16:45:36 GMT 2023 , Edited by admin on Sat Dec 16 16:45:36 GMT 2023
PRIMARY
MESH
C119593
Created by admin on Sat Dec 16 16:45:36 GMT 2023 , Edited by admin on Sat Dec 16 16:45:36 GMT 2023
PRIMARY
DRUG CENTRAL
2025
Created by admin on Sat Dec 16 16:45:36 GMT 2023 , Edited by admin on Sat Dec 16 16:45:36 GMT 2023
PRIMARY
SMS_ID
100000083073
Created by admin on Sat Dec 16 16:45:36 GMT 2023 , Edited by admin on Sat Dec 16 16:45:36 GMT 2023
PRIMARY
ChEMBL
CHEMBL2104734
Created by admin on Sat Dec 16 16:45:36 GMT 2023 , Edited by admin on Sat Dec 16 16:45:36 GMT 2023
PRIMARY
WIKIPEDIA
Oxomemazine
Created by admin on Sat Dec 16 16:45:36 GMT 2023 , Edited by admin on Sat Dec 16 16:45:36 GMT 2023
PRIMARY
EVMPD
SUB09549MIG
Created by admin on Sat Dec 16 16:45:36 GMT 2023 , Edited by admin on Sat Dec 16 16:45:36 GMT 2023
PRIMARY
CAS
156576-01-1
Created by admin on Sat Dec 16 16:45:36 GMT 2023 , Edited by admin on Sat Dec 16 16:45:36 GMT 2023
SUPERSEDED
MERCK INDEX
m8315
Created by admin on Sat Dec 16 16:45:36 GMT 2023 , Edited by admin on Sat Dec 16 16:45:36 GMT 2023
PRIMARY Merck Index
EPA CompTox
DTXSID5023405
Created by admin on Sat Dec 16 16:45:36 GMT 2023 , Edited by admin on Sat Dec 16 16:45:36 GMT 2023
PRIMARY
CAS
3689-50-7
Created by admin on Sat Dec 16 16:45:36 GMT 2023 , Edited by admin on Sat Dec 16 16:45:36 GMT 2023
PRIMARY
PUBCHEM
19396
Created by admin on Sat Dec 16 16:45:36 GMT 2023 , Edited by admin on Sat Dec 16 16:45:36 GMT 2023
PRIMARY
ACTIVE MOIETY
Structure of OXOMEMAZINE
SALT/SOLVATE (PARENT)
Structure of OXOMEMAZINE HYDROCHLORIDE
NIH
NCATS
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